Bronchodilating Plasma Concentrations of Enprofylline and Theophylline have Minor Cardiovascular Effects in Man

Abstract: The cardiovascular effects with bronchodilating plasma concentration of theophylline (3.8–12.6 mg/l) and enprofylline (0.8–3.0 mg/l) were studied in six healthy male subjects by means of non-invasive procedures. With these plasma concentrations only minor effects were noted with regard to heart rate, blood pressure and systolic time intervals. However, both xanthines seem to have a vasodilating ability and a weak positive inotropic effect on the heart.