| Abstract: | The aromatic amino acids L-tryptophan, L-tyrosine and L-phenylalanine complex with gossypol at pH 7.6, resulting in negative CD bands at 424–426 nm and 300 nm and a positive band at 355 nm. The association constant and free energy change for complex formation have been calculated from the amplitude of the CD band at 420 nm. The interaction is weak. The association constant for complex formation increases with the hydrophobicity of amino acid. The effect of additives on the reaction has also been determined. |
