小儿肠胃康颗粒联合蒙脱石散治疗小儿轮状病毒性肠炎的临床研究

目的探讨小儿肠胃康颗粒联合蒙脱石散治疗小儿轮状病毒性肠炎的临床疗效。方法选取2019年2月—2021年4月天津市宁河区医院儿科收治的90例轮状病毒性肠炎患儿作为研究对象,按照随机数字表法将所有患儿分为对照组和治疗组,每组各45例。对照组患儿口服蒙脱石散,6个月～1岁,1次/d,3 g/次;1～2岁,2次/d,3 g/次;2岁以上,3次/d,3 g/次。治疗组患儿在对照组治疗的基础上温水冲服小儿肠胃康颗粒,3次/d,5 g/次。两组患儿连续治疗5 d。观察两组的临床疗效,比较两组患儿大便频次、退热时间、止泻时间、止吐时间以及血清中C反应蛋白(CRP)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8)水平。结果治疗后,治疗组患儿的总有效率(93.33%)比对照组(77.78%)高,组间比较差异具有统计学意义(P0.05)。治疗后,两组的大便频次显著降低(P0.05),治疗组的大便频次明显低于对照组(P0.05)。治疗后,治疗组的退热时间、止泻时间、止吐时间短于对照组,差异有统计学意义(P0.05)。治疗后,两组的血清CRP、IL-6、IL-8水平显著降低(P0.05),治疗组血清CRP、IL-6、IL-8水平明显低于对照组(P0.05)。结论小儿肠胃康颗粒联合蒙脱石散可提高小儿轮状病毒性肠炎的临床疗效,减轻主要临床症状,降低炎症反应。

Clinical study on Xiaoer Changweikang Granules combined with Montmorillonite Powder in treatment of infantile rotavirus enteritis

Objective To investigate the clinical efficacy of Xiaoer Changweikang Granules combined with Montmorillonite Powder in treatment of infantile rotavirus enteritis. Methods Children (90 cases) with infantile rotavirus enteritis in Department of Pediatrics, Tianjin Ninghe Hospital from February 2019 to April 2021 were divided into control and treatment groups according to the random number table method, and each group had 45 cases. Children in the control group were po administered with Montmorillonite Powder, 6 months-1 year old, once daily, 3 g/time; 1-2 years old, twice daily, 3 g/time; Over 2 years old, three times daily, 3 g/time. Children in the treatment group were po administered with Xiaoer Changweikang Granules on the basis of the control group, three times daily, 5 g/time. Children in two groups were treated for 5 d. After treatment, the clinical efficacies were evaluated, and stool frequency, antipyretic time, antidiarrheal time, antiemetic time, and the serum levels of CRP, IL-6, and IL-8 in two groups were compared before and after treatment. Results After treatment, the total effective rate of the treatment group (93.33%) was higher than that of the control group (77.78%), and there was significant difference between the groups (P<0.05). After treatment, the stool frequency of two groups were significantly decreased (P<0.05), and the stool frequency of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the antipyretic time, antidiarrheal time, and antiemetic time in the treatment group were shorter than those in the control group (P<0.05). After treatment, the serum levels of CRP, IL-6, and IL-8 in the treatment group were significantly lower than those in the control group (P<0.05). Conclusion Xiaoer Changweikang Granules combined with Montmorillonite Powder can improve the curative effect of infantile rotavirus enteritis, reduce the main clinical symptoms, and reduce the inflammatory reaction.