Solution synthesis of antigenic and inhibiting peptides of the human renin prosegment-1 |
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| Authors: | JEAN-ALAIN FEHRENTZ,REN E SEYER,ANNIE HEITZ,PIERRE FULCRAND,BERTRAND CASTRO,PIERRE CORVOL |
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| Affiliation: | JEAN-ALAIN FEHRENTZ,RENÉE SEYER1,ANNIE HEITZ,PIERRE FULCRAND,BERTRAND CASTRO,PIERRE CORVOL |
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| Abstract: | The [Tyr47, Nle53] preprorenin (47–60) peptide methyl ester, a tetradecapeptide related to the human renin prosegment, has been synthesized using a three-segment coupling strategy. Selective deprotection of the segments before coupling allowed an easy removal of the final tetradecapeptide side chain-protecting groups by acidolysis and an easy purification. Antibodies raised against this peptide bound the plasmatic inactive renin. |
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| Keywords: | solution peptide synthesis segment coupling strategy renin selective deprotection synthetic hapten |
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