雷公藤多甙在大鼠胰、十二指肠移植中的作用

目的 解胰腺移植术后应用雷公藤多甙对移植胰腺功能存活的影响。方法 供体为雄性Ｗｉｓｔｅｒ大鼠，受体为雄性ＳＤ大鼠。受体经尾静脉注射链脲霉素５０ｍｇ／ｋｇ制备成糖悄病大鼠模型。胰腺４移植受用全胰腺、十二指肠移植，胰岛素回流采用门腔静脉吻合的体循环回流，外分泌胰液采用 受体十二指肠间侧侧吻合的肠引流法。血管吻合采用显微外科技术。胰腺移植术后开始每隔采用供受体十二指肠间侧侧吻合的肠引流法。血管吻合采用显

Role of tripterium wilfldii hook f.(T11)on pancreaticoduodenal allograft in rats

Objective To study the effects of tripterium wilfordii hook f.(T11) used after transplantation on survival of pancreas graft.Methods Male Wistar rats weighing 200-300 g served as donors, while recipients were male SD rats rendered diabetes with strepotozotocin administered intravenously at a dose of 50 mg/kg body weight through tail vein.Vascularized heterotopic whole organ panereaticoduodenal transplantation was performed.The graft exocrine secretion was drained into duodenum by side-to-side anastomoses between the duodenum of donor and recipient.The insulin was drained into systemic vena by anastomoses between inferior vena cava and the infrarenal abnominal aorta of recipient and the donor aorta and portal vein.The vascular anastomoses were done by using microsurgical method.The non-fasting serum glucose and urine glucose reaction were detected at an interval of 2 days and the serum insulin Wasdetected at the 4th day post-transplantation.Results All of the recipients had normoglyeemia and negative urine glucose reaction 24 h after transplantation.The survival time of the pancreatic grafts was as follows: (10.4±2.9)days in group 1,(22.0±1.5)days in group 2.Conclusion Administration of T11 after pancreatic transplantation could prolong the pancreatic graft survival.