Role of P2X and P2Y receptors in rat myocardial contractility during ontogeny |
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| Authors: | T. A. Anikina G. A. Bilalova A. A. Zverev F. G. Sitdikov |
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| Affiliation: | (1) Department of Anatomy, Physiology, and Human Health Protections, Kazan State Liberal Pedagogical University, Russia |
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| Abstract: | Stable agonist of P2 receptors 2-methylthio-ATP and selective antagonists of P2X and P2Y receptors PPADS and reactive blue-2 were used for evaluation of the role of P2 receptors in positive contractile reaction of atrial and ventricular myocardium in rats. PPADS significantly moderated the effects of 2-methylthio-ATP in 14-, 21-, and 56-day-old rat pups, but potentiated them in 100-day-old rats. Under conditions of reactive blue-2 treatment, the positive effect of the agonist was preserved in the atria and ventricles in all age groups and was age-dependent. __________ Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 143, No. 6, pp. 637–640, June, 2007 |
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| Keywords: | P2X and P2Y receptors myocardial strips contractility ontogenesis |
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