| 全脑照射加Vm-26治疗肺癌脑转移临床研究 |
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| 引用本文： | 葛立本,赵凯军,陶育纯.全脑照射加Vm-26治疗肺癌脑转移临床研究[J].中华肿瘤防治杂志,2005,12(15):1168-1169. |
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| 作者姓名： | 葛立本 赵凯军 陶育纯 |
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| 作者单位： | 吉林大学第二临床医院放疗科,吉林,长春,130021;吉林大学中日联谊医院电诊科,吉林,长春,130031;吉林大学公共卫生学院流行病与卫生统计学教研室,吉林,长春,130021 |
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| 摘 要： | 目的观察Vm-26配合全脑放疗与单纯放疗治疗肺癌脑转移的疗效、生存时间及不良反应。方法将60例肺癌脑转移患者随机分为单纯放疗组(放疗组30例)和放化疗综合组(综合组30例)。放疗组全脑常规放疗40Gy/4周。综合组放疗方法与单纯放疗组相同,放疗第1天开始给药,Vm-2660mg/m2,1次/周。结果放疗组和综合组总有效率分别为80.0%(24/30)和83.3%(25/30)。治疗后中位生存时间放疗组为5.4个月,综合组为7.6个月。两组中位生存时间比较差异有统计学意义,Z=2.365,P=0.0180,综合组骨髓抑制和胃肠反应高于放疗组,但大部分患者能耐受。结论肺癌脑转移患者全脑放疗加Vm-26可以延长生存时间。
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| 关 键 词： | 肺肿瘤/药物疗法 肺肿瘤/放射疗法 脑肿瘤/药物疗法 脑肿瘤/放射疗法 脑肿瘤/继发性 替尼泊甙/治疗应用 综合疗法 |
| 文章编号： | 1009-4571(2005)15-1168-02 |
| 修稿时间： | 2005年6月2日 |
Clinical research for treatment of brain metastases of lunch cancer |
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| GE Li-ben,ZHAO Kai-jun,TAO Yu-chun.Clinical research for treatment of brain metastases of lunch cancer[J].Chinese Journal of Cancer Prevention and Treatment,2005,12(15):1168-1169. |
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| Authors: | GE Li-ben ZHAO Kai-jun TAO Yu-chun |
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| Institution: | GE Li-ben1,ZHAO Kai-jun2,TAO Yu-chun3 1.Department of Radiotherapy,Second Hospital of Jilin University,Changchun 130021,P.R.China 2.Department of Ultrasound,China-Japan Union Hospital of Jilin University,Changchun 130031,P.R.China 3.Department of Epidemiology and Health Statistics,School of Public Health,Jilin University,Changchun 130021,P.R.China |
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| Abstract: | OBJECTIVE:To study the therapeutic effects of brain metastases from lung cancer by radiotherapy combined with chemotherapy and raidothrapy alone. METHODS: Sixty cases with brain metastases from lung cancer were randomly divided into 2 groups (30 cases in each group), including a simple irradiation group receiving whole brain irradiation to a total dose of 40 Gy, and a combined group receiving the same radiotherapy plus Vm-26. RESULTS: The effective rate of combined group (83.3%) was not significantly higher than that of simply irradiation group (80.0%).The middle-survival was 5.4 months in irradiation group and 7.6 months in combined group respectively,with significant difference,Z=2.365,P=0.018 0.The side effects including gastrointestinal tract reaction and myelosuppression in combined group was higher than those in irradiation group.But almost all the patients can tolerate the side effects. CONCLUSION: The patients suffered from brain metastases from lung cancer can prolong the survival time by radiotherapy combined with chemotherapy. |
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| Keywords: | lung neoplasms/drug therapy lung neoplasms/radiotherapy brain neoplasms/drug therapy brain neoplasms/radiotherapy brain neoplasms/secondary teniposide/therapeutic use combined modality therapy |
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