| 海洛因成瘾大白鼠脑内神经元凋亡的超微结构观察 |
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| 引用本文： | 韦献良,叶峻,周燕.海洛因成瘾大白鼠脑内神经元凋亡的超微结构观察[J].广西医科大学学报,2004,21(1):31-33. |
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| 作者姓名： | 韦献良 叶峻 周燕 |
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| 作者单位： | 广西医科大学,南宁,530021 |
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| 基金项目： | 广西壮族自治区科学研究与技术开发计划项目 (桂科攻 0 0 15 0 5 0 )，广西教育厅科研项目 ( 2 0 0 3年 ) |
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| 摘 要： | 目的：研究海洛因成瘾大白鼠脑内神经元凋亡的超微结构变化。方法：采用递增法人为建立海洛因成瘾动物模型．设对照组和模型组，取两组动物多部位脑组织电镜下观察超微结构改变。结果：电镜下清晰观察到海洛因成瘾大白鼠脑内多部位神经元凋亡各期的超微结构变化。正常对照组电镜超微影像正常。结论：海洛因成瘾大白鼠脑组织广泛出现神经元凋亡．这是海洛因成瘾致脑神经元死亡的主要形式．神经元凋亡的超微结构改变既具有细胞凋亡的一般形态特征也呈现一定的特异性。
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| 关 键 词： | 海洛因成瘾 脑神经元 凋亡 超微结构 |
| 修稿时间： | 2003年9月4日 |
OBSERVATION OF THE ULTRASTRUCTURAL CHANGES OF NEURONAL APOPTOSIS IN THE BRAIN OF HEROIN-ADDICTED RATS |
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| Wei Xianliang,Ye Jun,Zhou Yan..OBSERVATION OF THE ULTRASTRUCTURAL CHANGES OF NEURONAL APOPTOSIS IN THE BRAIN OF HEROIN-ADDICTED RATS[J].Journal of Guangxi Medical University,2004,21(1):31-33. |
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| Authors: | Wei Xianliang Ye Jun Zhou Yan |
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| Abstract: | Objective:To study the ultrastructure characteristics of neuronal apoptosis of the brain in the heroin addictive rats.Methods:The animals were randonly divided into the control and model groups.The animal model of heroin addiction was made by means of progressively increasing doses. The brain tissues from the animals of the two groups were observed by electronic microscope.Result:The ultrastructural changes of neuronal apoptosis in various periods appeared clearly in the brain tissues of the heroin addictive rats,while none was detected in control group.Conclusion:Neuronal apoptosis appeared widely in the brains of heroin addictive rats, and apoptosis is the main reason for brain Neuronal death caused by heroin addiction. neuronal apoptosis shows specific ultrastructrual characteristics besides sharing the common characteristics of cellwlar apoptosis. |
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| Keywords: | heroin addiction neuron apoptosis ultrastructure |
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