分离自肿瘤患者穿通支原体体外药物敏感性试验

目的研究分离自肿瘤患者穿通支原体体外药物敏感性。方法选择左旋氧氟沙星等7种抗菌药物对15株分离自肿瘤患者的穿通支原体进行最低抑菌浓度（MICs）和最低杀菌浓度（MBCs）测定。 结果其中MICs以克林霉素和左旋氧氟沙星最低（0.078 g/ml），其他依次为:环丙沙星（0.156 g/ml）、红霉素（0.156 g/ml）、氯霉素（0.312 g/ml）、氧氟沙星（8 g/ml）、庆大霉素（10 g/ml）。MBCs最低的是克林霉素和左旋氧氟沙星（0.156 g/ml）。结论克林霉素、左旋氧氟沙星可作为穿通支原体感染治疗的首选药物。

In vitro drug susceptibility test of Mycoplasma penetrans isolated from cancer patients

Objective To study the in vitro drug susceptibility of Mycoplasma penetrans （M. penetrans） isolated from cancer patients. Methods The minimal inhibitory concentrations （MICs） and minimal bactericidal concentrations （MBCs） of 7 antibiotics including levofloxacin to 15 strains of M. penetrans were performed. Results The MICs of clindamycin and levofloxacin were the lowest （0.078 μg/ml）, followed by ciprofloxacin（0.156 μg/ml）, erythromycin （0. 156μg/ml）, chloramphenicol （0. 312 μg/ml）, ofloxacin （8 μg/ml） and gentamicin （10 μg/ml）. The MBCs of clindamycin and levofloxacin were the lowest （0. 156μg/ml）. Conclusion Clindamycin and levofloxacin might be the first choice of antibiotics for the treatment of M. penetrans infection.