| 血管性痴呆患者治疗前后视觉P300的变化 |
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| 引用本文： | 童春南,俞波,张载福,楼翡璎,陈冲.血管性痴呆患者治疗前后视觉P300的变化[J].上海精神医学,2010,22(2):97-99,104. |
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| 作者姓名： | 童春南 俞波 张载福 楼翡璎 陈冲 |
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| 作者单位： | 1. 金华市第二医院精神科,321016
2. 上海交通大学医学院附属精神卫生中心,200030 |
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| 摘 要： | 目的探讨事件相关电位视觉P300在血管性痴呆（VaD）患者认知功能评估中的价值。方法应用Nicolet脑诱发电位仪对39例VaD患者分别在多奈哌齐治疗前和治疗32周后进行视觉P300检测,并与34例健康老人作对照,使用简易精神状况检查（MMSE）评估患者的认知功能。结果治疗前VaD组MMSE（16.4±3.9）分]分值显著低于健康对照组（28.0±1.5）分]。视觉P300表现为P2、N2、P3靶刺激潜伏期延长,靶刺激P2、P3波幅低,非靶刺激P2波幅低。治疗后VaD患者认知功能改善,其视觉P300主要表现为P3潜伏期缩短,P3波幅增高。结论视觉P300有助于反映VaD患者认知功能的变化,P300这一指标的变化值得进一步跟踪随访。
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| 关 键 词： | 血管性痴呆 认知障碍 视觉P300 多奈哌齐 |
Changes in event-related potentials visual P300 in vascular dementia before and after treatment |
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| Tong Chunnan,Yu Bo,Zhang Zaifu,Lou Feiying,Chen Chong..Psychiatry.Changes in event-related potentials visual P300 in vascular dementia before and after treatment[J].Shanghai Archives of Psychiatry,2010,22(2):97-99,104. |
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| Authors: | Tong Chunnan Yu Bo Zhang Zaifu Lou Feiying Chen ChongPsychiatry |
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| Institution: | Tong Chunnan1,Yu Bo1,Zhang Zaifu1,Lou Feiying2,Chen Chong2.1.Psychiatry Department,The Second Hospital of Jinhua,Jinhua 321016,2.Department of Electrophysiology,Shanghai Mental Health Center,Shanghai Jiaotong University,Shanghai 200030 |
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| Abstract: | Objective: To understand role of event-related potentials visual P300 in evaluation of cognitive function in vascular dementia(VaD).Methods: With Nicolet instrument,visual P300 test and Mini-Mental State Examination(MMSE) assessment were carried out in 39 patients met NINCDS-AIREN criteria of VaD at baseline and after 32 weeks of treatment.34 healthy elderlies were also assessed as control group.Results:At baseline,MMSE score was lower in VaD patients than in control group(P<0.01).VaD patients had significa... |
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| Keywords: | Vascular dementia Cognition disorders Visual P300 Donepezil |
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