中青年缺血性脑卒中危险因素的对照研究

背景缺血性脑卒中发病呈年轻化趋势,因此研究中青年脑卒中的危险因素,进行一级康复预防有着极其重要的临床意义.目的探讨中青年缺血性脑卒中的危险因素.设计以诊断为依据的病例-对照分析.单位一所大学医院的神经内科.对象脑卒中组100例为1997-07/2000-12中南大学湘雅二医院神经科住院患者,其中青年(＜44岁)患者63例,老年前期(45～49岁)患者37例,平均年龄(42.91±6.38)岁.另随机收集同期100例无脑血管病史的外科病患者为对照组,年龄(42.70±2.98)岁,中青年组61例,老年前期组39例.方法两组进行12项危险因素对照研究,并将中青年和老年前期分别与对照组进行比较.主要观察指标各组各项危险因素患病率比较.结果高血压病、高脂血症、心电图异常、脑卒中家族史、眼底动脉硬化、糖尿病、风湿性心脏病是中青年缺血性脑卒中的危险因素.结论降低血压、血脂水平对预防缺血性卒中发生有极其重要的意义.

Comparative analysisof the risk factors of ischemic stroke in the middle-aged and youth

BACKGROUND: Ischemic stroke has a younger tendency; hence to explore the risk factors of stroke in the middle-aged and youth for primary rehabilitation has extremely important clinical significance.OBJECTIVE: To investigate the risk factor-of stroke in the middle-aged and youth.DESIGN: A case-control analysis based on diagnose.SETTING: Department of neurology in a university hospital.PARTICIPANTS: Totally 100 hospitalized patients including the middle-aged and youth ( ＜ 44 years old, n = 63 ) and the pre-elderly (45 - 49years old, n = 37) with mean age of(42. 91 ±6.8) were selected into stroke group from the Department of Neurology, Xiangya Second Hospital, Central South University between July 1997 and December 2000. Another 100 surgical patients without history of cerebrovascular diseases aged(42.70 ± 2.98) including the middle-aged and youth( n = 61 ) and the pre-elderly( n = 39) were collected randomly from the same corresponding period as control gruop.METHODS: A comparative study of 12 risk factors between two groups was studied and compared the middle-aged group and youth, the pre-elderly group with control group.MAIN OUTCOME MEASURES: Morbidity comparison of each risk factor in each group.RESULTS: Hypertension, hyperlipemia, abnormal electrocardiogram (ECG),family history of stroke, arteriosclerosis of the eyeground, diabetes, and rheumatic heart disease are risk factors of ischemic stroke in the middle-aged.CONCLUSION: It is extremely important significance to reduce blood pressure and blood-fat level in the prevention of ischemic stroke.