| 卵泡发育与端粒酶表达及调控 |
| |
| 引用本文： | 张静,郑月慧,吴凌峰.卵泡发育与端粒酶表达及调控[J].生殖医学杂志,2005,14(2):117-119. |
| |
| 作者姓名： | 张静 郑月慧 吴凌峰 |
| |
| 作者单位： | 江西医学院生理教研室,南昌,330006 |
| |
| 基金项目： | 国家自然科学基金(30260035)，江西省自然科学基金(9940001)资助 |
| |
| 摘 要： | 端粒酶是一种核糖核蛋白,具有合成端粒的功能。细胞的年龄和寿命与端粒酶的活性和端粒的长度密切相关。卵巢是一个以周期性的细胞增殖分化和凋亡为特征的器官,在正常的卵巢中端粒酶的表达随卵泡发育的不同阶段而变化。故卵巢端粒酶的活性是衡量卵泡功能的重要指标。端粒酶活性受雌激素和孕激素调控,并且均通过有丝分裂原激活蛋白激酶(MAPK)路径介导。
|
| 关 键 词： | 端粒 端粒酶 卵巢 |
| 文章编号： | 1004-3845(2005)02-0117-03 |
| 修稿时间： | 2003年9月11日 |
Expression and regulation of telomerase in follicular development |
| |
| ZHANG Jing,ZHENG Yue-hui,WU Ling-feng.Expression and regulation of telomerase in follicular development[J].Journal of Reproductive Medicine,2005,14(2):117-119. |
| |
| Authors: | ZHANG Jing ZHENG Yue-hui WU Ling-feng |
| |
| Institution: | ZHANG Jing,ZHENG Yue-hui,WU Ling-fengDepartment of Physiology,Jiangxi Medical College,Nanchang 330006 |
| |
| Abstract: | Telomerase is the ribonuclear enzyme that synthesizes telomere. The age and life span of the cells are closely correlated to the presence of the telomerase activity and the length of the telomere. (Ovary) is an organ that executes cell proliferation and apoptosis periodically. The expression of telomerase has been detected in normal ovary, and its levels change accordingly with the developmental stage of the follicles. Ovarian telomerase activity is, therefore, an important marker of follicular function. The telomerase activity is regulated by both estrogen and progesterone and this regulation is mediated through the mitogen-activated protein kinase pathway. |
| |
| Keywords: | Telomere Telomerase Ovary |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
