| 膀胱癌组织中端粒酶活性测定 |
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| 引用本文： | 唐正严 易红 等. 膀胱癌组织中端粒酶活性测定[J]. 湖南医科大学学报, 2001, 26(2): 167-168 |
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| 作者姓名： | 唐正严 易红 等 |
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| 摘 要： | 目的：探讨端粒酶活性与膀胱癌之间的关系。方法：采用Telomerase PCR ELISA法对41例膀胱部组织和23例非癌患者膀胱组织中端粒酶活性进行检测。结果：41例膀胱癌组织中端粒酶阳性34例，阳性率82.9%，23例非癌患者膀胱组织中端粒酶阳性1例，阳性率4.3%。两组端粒酶活性比较，阳性率差异有显著性（P＜0.01)。结论：端粒酶活性与膀胱癌之间密切相关，端粒酶活化可能是膀胱癌发生及发展过程中的重要分子事件。端粒酶可作为早期发现膀胱癌、术后随诊的分子生物学标记。
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| 关 键 词： | 膀胱肿瘤 端粒酶 聚合酶链反应 PCR ELISA 活性 |
Telomerase activity in bladder cancer tissues] |
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| Z Y Tang,H Yi,B L Chen. Telomerase activity in bladder cancer tissues][J]. Bulletin of Hunan Medical University, 2001, 26(2): 167-168 |
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| Authors: | Z Y Tang H Yi B L Chen |
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| Affiliation: | Department of Urology, Xiangya Hospital, Central South University, Changsha 410008, China. |
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| Abstract: | OBJECTIVE: To study the correlation between telomerase and bladder cancer. METHODS: The telomerase activity was detected by telomerase PCR ELISA in 41 cases of bladder cancer tissues and 23 cases of non-cancerous bladder tissues. RESULTS: The telomerase activity was positive in 34 cases of bladder cancer tissues (82.9%) and 1 case of non-cancerous tissues (4.3%); the difference of positive rate was significant (P < 0.01). CONCLUSIONS: Telomerase activity is related with bladder cancer closely; telomerase activation may be an important molecular step in the initiation and development of bladder cancer; telomerase may be an excellent molecular biomarker in finding bladder cancer at an early stage and in postoperative following-up. |
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