Complement fixing abilities of IgA myeloma protiens and their fragments: The activation of complement through the classical pathway |
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| Affiliation: | 1. Center for Translational Immunology, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands;2. Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands;3. Nanomedicine Research and Education Center, Institute of Translational Medicine, Semmelweis University, Budapest, Hungary;4. SeroScience LCC, Budapest, Hungary;5. Department of Nanobiotechnology and Regenerative Medicine, Faculty of Health, Miskolc University, Miskolc, Hungary;6. Department of Surgery, Nanomedicine Translational Programme, NUS Center for Nanomedicine, Yong Loo Lin School of Medicine, University of Singapore, Singapore;7. CDL Research, University Medical Center Utrecht, Utrecht University, Utrecht, the Netherlands;1. Center for Cerebral and Cardiovascular Disease Information, National Cerebral and Cardiovascular Center, Suita, Japan;2. Department of Preventive Medicine and Epidemiologic Informatics, National Cerebral and Cardiovascular Center, Suita, Japan;3. Department of Public Health and Policy, University of Liverpool, Liverpool, UK;4. International Center for Nutrition and Information, National Institute of Health and Nutrition, National Institutes of Biomedical Innovation, Health and Nutrition, Tokyo, Japan;5. Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan;6. Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, USA;7. First Department of Internal Medicine, Nara Medical University, Kashihara, Japan;8. Department of Health Services Research, Faculty of Medicine, University of Tsukuba, Tsukuba, Japan;9. Department of Public Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;10. Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Tokyo, Japan;11. Faculty of Nursing, School of Health Science, Fujita Health University, Toyoake, Japan |
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| Abstract: | Complement fixing abilities of IgA and its fragments chemically aggregated were tested. Both IgA1 and IgA2 myeloma proteins fixed considerable amount of human complement. IgA2 fixed complement more efficiently than IgA1 did. Fc and F(ab′)2 of IgA1 were more active than undigestived IgA1, and their activities were comparable to that of Fc of IgG, whereas the activity of F(ab′)2 of IgA2 was weak. Complement component profiles of human serum treated either IgA or its fragments revealed that the classical pathway of the complement system was activated. |
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