皮下脂膜炎性T细胞淋巴瘤临床病理分析

目的分析皮下脂膜炎性Ｔ细胞淋巴瘤的病理形态和生物学行为特点,并对其分类命名作一探讨。方法用ＨＥ和免疫组化ＡＢＣ方法对４例原发并定位于皮下脂肪组织中的Ｔ细胞淋巴瘤进行临床病理学和免疫组织化学观察。结果４例病人均表现１～３ｃｍ的皮下结节,伴高热,临床经过凶猛,短期死亡。组织学上以肿瘤细胞（ＣＤ４５ＲＯ阳性）浸润脂肪小叶之间及大量豆袋细胞（ｂｅａｎｂａｇｃｅｌ,ＣＤ６８阳性）为特征。结论皮下脂膜炎性Ｔ细胞淋巴瘤是一种恶性度很高的外周Ｔ细胞淋巴瘤。

A clinicopathological study on panniculitic T-cell lymphoma

Objective To analyse the pathomorphology and clinical behavior of panniculitic T cell lymphoma (PTCL) and to study the classification and name of PTCL. Methods Routine pathological and immunohistochemical methods were utilized to analyse 4 cases of PTCL. Results All patients presented with 1 to 3 cm diameter subcutaneous nodules accompanied by high fever. The clinical course of these patients was distinctive and progressive. All patients died within 4 9 months. Histologically, the lesions were composed of medium sized atypical cells (CD45RO ) infiltrating between fat cells, large numbers of bean bag cells (CD68 ) could be observed. Conclusions PTCL is a type of pereipheral T cell lymphoma which is highly malignant.