雌激素配伍孕激素在吸宫术后预防宫腔粘连的作用

目的探讨雌激素配伍孕激素在吸宫术后预防宫腔粘连的作用。方法选取2003~2013年在成都市计划生育指导所诊断为胚胎停育患者230例,分为A、B两组。A组(117例)吸宫术后当日给予口服戊酸雌二醇,后半周期加服醋酸甲羟孕酮,B组(113例)术后未服用雌、孕激素。对两组患者术后子宫内膜连续性差者行宫腔镜检查,了解宫腔粘连的发生情况。结果 A组术后子宫内膜连续性差者17例,宫腔粘连4例(3.4%);B组子宫内膜连续性差者41例,宫腔粘连24例(21.2%),两组差异有统计学意义(P0.05)。结论吸宫术后立即用外源性雌激素配伍孕激素对防止宫腔粘连能起到一定的预防作用。

The effect of estrogen and progesterone in prevention of intrauterine adhesion after uterine aspiration

Objective To investigate the effect of estrogen and progesterone in prevention of intrauterine adhesion after uterine aspiration. Methods 230 cases with embryonic diapausecases in Chengdu Family Planning Consulting Institute from 2003 to 2013 were selected and divided into 2 groups. Patients in group A（117 cases）took estradiol valerate immediately after uterine aspiration,adding medroxyprogesterone in the second cycle. Patients in group B（113 cases）didn’t take estrogen nor progesterone. Patients with endometrial poor continuity in both groups were conducted hysteroscopy to detect the intrauterine adhesion. Results 17 cases in group A were detected with endometrial poor continuity and 4 cases with intrauterine adhesion（3. 4%）;41 cases in group B were detected with endometrial poor continuity and 24 cases with intrauterine adhesion（ 21. 2%）. There was significant difference between two groups（P〈0. 05）. Conclusion To use estrogen and progesterone after uterine aspiration immediately can prevent intrauterine adhesion.