支原体感染与输卵管性不孕相关性及药敏变迁的分析

目的探讨支原体感染与输卵管性不孕的相关性及其药敏变迁,为指导临床合理用药提供参考。方法选择2011~2013年在广州市天河区人民医院妇产科就诊的输卵管性不孕患者345例为观察组,按年龄、职业、文化程度和营养状况1∶1匹配正常孕妇345例为对照组,用微生物检验法,作支原体培养及药敏测定。结果观察组解脲支原体(Ureaplasma urealyticum,Uu)、人型支原体(Mycoplasma hominis,Mh)和Uu+Mh检出率(67.25%,8.12%,2.61%)均高于对照组(15.94%,1.74%,0.58%)(P0.05);观察组中138例输卵管完全阻塞患者与207例部分阻塞患者的Uu、Mh和Uu+Mh检出率差异无统计学意义(P0.05);Uu对交沙霉素、美满霉素和强力霉素表现出较高较稳定的敏感性(88.78~78.95%);Mh和Uu+Mh对美满霉素、交沙霉素和强力霉素均高度敏感(88.24%~90.91%)。结论生殖道支原体感染与不孕症具有相关性;监测其药敏及变迁有助于合理用药。

Analysis of the relationship between the reproductive tract infection of mycoplasma and tubal infertility and transition of drug sensitivity

Objective To explore the relationship between the reproductive tract infection of mycoplasma and tubal infertility and transition of drug sensitivity,to offer reference for clinical rational drug use. Methods 345 cases with tubal infertility in Tianhe District First Peopleˊs Hospital of Guangzhou City from 2011 to 2013 were selected as observation group,345 normal pregnant women matching to observation group according to age,occupation, cultural degree and nourishment condition were selected as control group. Mycoplasma culture and drug sensitivity were tested with microbiological test. Results The infectious rate of Ureaplasma urealyticum（ Uu）,Mycoplasma＆amp;nbsp;hominis（Mh）and Uu＋Mh were 67. 25%,8. 12% and 2. 61% respectively in observation group,which were higher than control group（15. 94%,1. 74% and 0. 58%）（P〈0. 05）. However,the infectious rate of Uu,Mh and Uu＋Mh in 138 cases with complete tubal obstruction showed no significant differences compared to 207 cases with partial tubal obstruction（P〉0. 05）. Josamycin,Minocycline and Doxycycline showed stable sensitivity to Uu（88. 78% ~78. 95%）. Minocycline,Josamycin and Doxycycline showed high sensitivity to Mh and Uu ＋ Mh（ 88. 24% ~90. 91%）respectively. Conclusion Mycoplasma infection of reproductive tract has relation with tubal infertility, monitoring drug sensitivity of Mycoplasma is important for using medicine rationally.