Comparison of radionuclide estimation of glomerular filtration rate using technetium 99m diethylenetriaminepentaacetic acid and chromium 51 ethylenediaminetetraacetic acid |
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Authors: | J S Fleming J Wilkinson R M Oliver D M Ackery G M Blake D G Waller |
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Institution: | (1) Present address: Department of Nuclear Medicine, Southampton General Hospital, S09 4XY Shirley, Southampton, UK;(2) Clinical Pharmacology Group, Southampton General Hospital, S09 4XY Shirley, Southampton, UK;(3) Present address: Middlesex Hospital, London, UK;(4) Present address: Guy's Hospital, London, UK |
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Abstract: | Simultaneous measurements of the clearance rates of technetium 99m diethylenetriaminepentaacetic acid (99mTc-DTPA) and chronium 51 ethylenediaminetetraacetic acid (51Cr-EDTA) were performed in 30 patients with a range of renal function (glomerular filtration rates between 9 and 120 ml/min). Using multiple blood samples, the two clearance values correlated well (r=0.991, standard error 3.9 ml/min), but DTPA clearance was systematically higher by 7.6%. For each radiopharmaceutical, an equation was derived to correct clearance values obtained using only plasma samples taken at 2 and 4 h for the systematic error inherent in this technique compared with analysis of the complete plasma concentration-time curve. The root mean square error remaining after application of these equations was 1.9 ml/min for both the EDTA and DTPA data. The corresponding errors obtained using the equation derived by Brochner-Mortensen for EDTA plasma clearance were 2.2 ml/min and 1.9 ml/min, respectively, these values were not significantly different from those obtained using the equations derived in this study. |
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Keywords: | Glomerular filtration rate Technetium 99m diethylenetriaminepentaacetic acid Chromium 51 ethylenediaminetetraacetic acid |
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