短期静脉应用胺碘酮治疗老年心房颤动的疗效分析

目的：观察短期静脉应用胺碘酮转复老年心房颤动的效果及安全性。方法：42例新发的老年房颤患者，静脉给予负荷量胺碘酮（150～300mg），并以1．0～0．5mg／min静脉维持，观察24h的转复效果及不良反应。结果：33例患者转复窦性心律（82．1％），其中1h内复律3例，1～8h内13例，8～24h内17例，复律后的心率、收缩压和舒张压均显著下降，未复律者的心室率也明显减慢（P〈0．01）。共出现3例窦性心动过缓，1例频发房性早搏，1例一过性低血压，1例静脉炎。结论：静脉应用胺碘酮转复老年新发房颤的短期成功率较高并且相对安全。

Effects of intravenous amiodarone in the short term on atrial fibrillation in the aged

Objective:To investigate the efficacy and safety of short-term intravenous amiodarone in the management of atrial fibrillation in the aged.Methods:Forty two patients with recent onset(within 24h) atrial fibrillation were treated with loading dose of amiodarone(150~300 mg) intravenously,followed by intravenous infusion of amiodarone with the rate at 1.0~0.5 mgmin.The conversion rate and adverse reactions within 24h were observed.Results:At 24h,sinus rhythm was restored in thirty three patients(82.1%),and at 1h,1~8h,8~24h,sinus rhythm was restored in three,thirteen and seventeen patients respectively,there were significant decrease in ventricular rate,systolic pressure and diastolic pressure after conversion to sinus rhythm(P<0.01);there was also a significant decreased ventricular rate in those who didn't restore to sinus rhythm(P<0.01).Sinus bradycardia was observed in three patients,one patient had frequent atrial premature beats,one patient had transient hypotension and one patient had phlebitis.Conclusion:Short-term intravenous amiodarone has a high conversion rate and relative safety in the treatment of recent onset atrial fibrillation in the aged.