Transmission clustering drives the onward spread of the HIV epidemic among men who have sex with men in Quebec |
| |
Authors: | Brenner Bluma G,Roger Michel,Stephens David,Moisi Daniela,Hardy Isabelle,Weinberg Jonathan,Turgel Reuven,Charest Hugues,Koopman James,Wainberg Mark A Montreal PHI Cohort Study Group |
| |
Affiliation: | McGill University AIDS Centre, Lady Davis Institute, Jewish General Hospital, Montreal, Quebec. bluma.brenner@mcgill.ca |
| |
Abstract: | Phylodynamic analysis and epidemiologic data identified 3 patterns of spread of primary human immunodeficiency virus type 1 infection (PHI) among men who have sex with men (2001-2009): 420 unique PHIs, 102 small clusters (2-4 PHIs per cluster, n = 280), and 46 large clusters (5-31 PHIs per cluster, n = 450). Large clusters disproportionately increased from 25.2% of PHIs in 2005 to 39.1% in 2009 (χ(2) = 33.9, P < .001). Scalar expansion of large clusters over 11 months (interquartile range, 3.5-25.5 months) correlated with cluster membership size (r(2) = 0.174, F = 4.424, P = .047). PHI cohort data revealed variations in social networks and risk behaviors among the 3 groups, suggesting the need for tailored prevention measures. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|