Involvement of GABAB receptors in the antinociception induced by baclofen in the formalin test |
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| Affiliation: | 1. Department of Physiology, Tarbiat Modarres University, Tehran Iran;2. Department of Physiology, Shaheed Beheshti University of Medical Sciences, P. O. Box 19835-181, Tehran, Iran Fax: (21) 6404680];3. Department of Pharmacology, Tehran University of Medical Sciences, Tehran, Iran;1. Department of Mechanical Engineering, MVSR Engineering College, Hyderabad 510510, India;2. Department of Mechanical Engineering, MVSR Engineering College, Hyderabad 510510, India;3. Department of Mechanical Engineering, MVSR Engineering College, Hyderabad 510510, India;1. The Key Lab of Pollution Control and Ecosystem Restoration in Industry Clusters, Ministry of Education, School of Environment and Energy, South China University of Technology, Guangzhou Higher Education Mega Centre, Guangzhou 510006, PR China;2. School of Life Sciences, Qufu Normal University, Qufu 273165, PR China;3. College of Environment & Resources, Fuzhou University, Fuzhou 350116, PR China;1. Department of Physiology, Faculty of Medicine, Helsinki, Finland;2. Department of Neuroscience and Biomedical Engineering, Aalto University School of Science and AMI Centre, Espoo, Finland;3. OrionPharma Inc., Turku, Finland;1. Faculty of Pharmacy, Eastern Mediterranean University, Famagusta, T.R. North Cyprus via Mersin 10, Turkey;2. Neurophysiology Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;3. Department of Animal Biology, Faculty of Biological Science, Kharazmi University, Tehran, Iran;4. Neuroscience Research Center, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran;1. Shandong University of Science and Technology, Mine Disaster Prevention and Control Ministry of State Key Laboratory Breeding Base, Qingdao 266590, PR China;2. University of Regina, Faculty of Engineering and Applied Science, 3737 Wascana Pkwy, Regina, SK, Canada |
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| Abstract: | - 1.1. The effect of GABA receptor antagonists on baclofen-induced antinociception was examined in rats using the formalin test. Intraperitoneal (IP) administration of different doses of baclofen (2.5–10 mg kg−1) to rats induced antinociception in both phases of the test.
- 2.2. The response was dose-dependent and the maximum response was observed with 10 mg kg−1 of the drug. Intracerebroventricular (ICV) injection of baclofen (0.5−20μg/rat) also induced dose-dependent antinociception in the second phase of the formalin test.
- 3.3. The GABAB antagonist, phaclofen (1 mg kg−1, IP) but not the GABAA antagonists picrotoxin (1 mg kg−1, IP) and bicuculline (1.5 mg kg−1, IP), decreased the antinociception induced by both ICV and IP administration of baclofen.
- 4.4. It is concluded that baclofen antinociception in the formalin test is mediated through GABAB receptor activation.
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