| 黄芩甙对缺血再灌注大鼠心肌损伤的保护作用 |
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| 引用本文： | 李晓蓉,孙薇,等.黄芩甙对缺血再灌注大鼠心肌损伤的保护作用[J].首都医学院学报,2001,22(2):107-109. |
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| 作者姓名： | 李晓蓉 孙薇 |
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| 作者单位： | [1]首都医科大学药理学教研室 [2]首都儿科研究所 |
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| 摘 要： | 采用大鼠心肌缺血再灌注模型观察黄芩甙对缺血再灌注后心律失常和心肌损伤的保护作用。实验大鼠分为假手术组、缺血再灌注组、黄芩甙I组、黄芩甙II组和维拉帕米组。观察对各组大鼠心电图、血清磷酸肌酸激酶(CPK)、谷胱甘肽过氧化物酶 (GSH PX)及心肌组织内超氧化物歧化酶 (SOD)、脂质过氧化物丙二醛 (MDA)的影响。结果表明 ,黄芩甙可显著减少再灌注性心律失常发生率 ,降低CPK活性和MDA含量 ,升高SOD和GSH PX活性。提示黄芩甙对再灌注心肌具有保护作用 ,其机制可能与其抗脂质过氧化反应有关
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| 关 键 词： | 黄芩甙 心肌缺血再灌注 心肌损伤 脂质过氧化物 超氧化物歧化酶 |
| 收稿时间： | 2000-09-29 |
| 修稿时间： | 2000年9月29日 |
Influence of Baicalin on Myocardium Ischemia-repurfusion Injury in Rats |
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| Li Xiaorong,Hei Ailian,Bao Lirong,Sun Songsan.Influence of Baicalin on Myocardium Ischemia-repurfusion Injury in Rats[J].Journal of Capital University of Medical Sciences,2001,22(2):107-109. |
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| Authors: | Li Xiaorong Hei Ailian Bao Lirong Sun Songsan |
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| Institution: | Li Xiaorong,Hei Ailian,Bao Lirong,Sun Songsan Department of Pharmacology,Capital University of Medical Sciences Sun Wei Capital Institute of Pediatrics |
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| Abstract: | Protective effects of baicalin on myocardium ischemia repurfusion injury were studied in rats. Wistar rats were divided into 5 groups: pseudo operation; ischemia reperfusion operation; ischemia reperfusion with baicalin 20 mg/kg and 80 mg/kg; ischemic reperfusion with Verapamil 1 mg/kg. The results showed that baicalin reduced frequency of arrhythmia, contents of CK and MDA, and increased activities of SOD and GSH PX. The results suggest that baicalin possesses protective effects on myocardium ischemia reperfusion injury in rats and its mechanism is related to inhibition of lipid peroxidation. |
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| Keywords: | baicalin myocardial ischemia-reperfusion myocardial injury lipid peroxides supero-xide dismutase |
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