| 奇正消痛贴膏对大鼠皮肤超微结构的影响和透皮吸收机理的研究 |
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| 引用本文： | 谢平,谷素敏,张天鹏,杜亚豪,吴志宏,李汇华. 奇正消痛贴膏对大鼠皮肤超微结构的影响和透皮吸收机理的研究[J]. 中国中医骨伤科杂志, 2008, 16(12): 22-23 |
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| 作者姓名： | 谢平 谷素敏 张天鹏 杜亚豪 吴志宏 李汇华 |
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| 作者单位： | [1]中国医学科学院基础医学研究所,北京100005 [2]北京协和医院,北京100005 |
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| 摘 要： | 目的：阐明奇正消痛贴膏快速透皮吸收的作用机理。方法：选用Wistar大鼠，于大鼠背部皮肤涂搽药剂，应用透射电镜观察该药对大鼠皮肤超微结构的影响。结果：用药后使皮肤角质层细胞间距明显增大，细胞结构变得疏松，外层细胞脱落。该药进入角质层细胞内，与细胞内基质相作用，引起基底角质层肿胀和水化程度增加。停药后3～5d，表皮角质层可基本恢复正常。结论：奇正消痛贴膏可明显降低皮肤对药物的屏障作用，并使基底角质层水化程度增加，从而增加了透皮吸收。
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| 关 键 词： | 奇正消痛贴膏 透皮吸收机理 超微结构 大鼠皮肤 |
Effect of Qizheng Xiaotong Plaster on Epidermal Ultrastructure and the Mechanism of Transdermal Absorption in Rats |
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| XIE Ping GU Sumin ZHANG Tianpeng DU Yahao WU Zhihong LI Huihua Peking Union Medical College , Chinese Academy of Medical Sciences,Beijing ,ChinaPeking Union Medical College Hospital,China. Effect of Qizheng Xiaotong Plaster on Epidermal Ultrastructure and the Mechanism of Transdermal Absorption in Rats[J]. Chinese Journal of Traditional Medical Traumatology & Orthopeics, 2008, 16(12): 22-23 |
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| Authors: | XIE Ping GU Sumin ZHANG Tianpeng DU Yahao WU Zhihong LI Huihua Peking Union Medical College & Chinese Academy of Medical Sciences Beijing ChinaPeking Union Medical College Hospital China |
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| Affiliation: | XIE Ping1 GU Sumin1 ZHANG Tianpeng1 DU Yahao1 WU Zhihong2 LI Huihua11 Peking Union Medical College & Chinese Academy of Medical Sciences,Beijing 100005,China2Peking Union Medical College Hospital,China |
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| Abstract: | Objective:To explore the mechanism of quick transdermal Absorption of Qizheng Xiaotong Plaster (QXP). Methods:Skin of back in Wistar rats was smeared with medicine. Transmission electron microscopy (TEM) was applied to observe the ultrastructural changes of skin. Results:The space between cells in stratum corneum was widened significantly; the cellular structure became loosing,with enveloping cells desquamated. The drug was able to penetrate into the stratum corneum cells and interacted with intracellular m... |
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| Keywords: | Qizheng Xiaotong Plaster Transdermal Absorption Ultrastructure Rat skin |
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