| Comparative study on the properties ofMDA－LDL＇s and o－LDL＇s receptors on macrophage |
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| 引用本文： | 丁振华,陈瑗,周玫,方允中. Comparative study on the properties ofMDA－LDL＇s and o－LDL＇s receptors on macrophage[J]. 中国人民解放军军医大学学报, 1994, 0(3) |
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| 作者姓名： | 丁振华 陈瑗 周玫 方允中 |
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| 作者单位： | Ding Zhenhua;Chen Yuan;Zhou Mei;Fang Yunzhong(Research Group of Lipoperoxidative Damage，First Military Medical University，Guangzhou，510515)(Institute of Radiation Medicine，Academy of Military Medical Sciences，Beijing，100850) |
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| 摘 要： | ＣｏｍｐａｒａｔｉｖｅｓｔｕｄｙｏｎｔｈｅｐｒｏｐｅｒｔｉｅｓｏｆＭＤＡ－ＬＤＬ＇ｓａｎｄｏ－ＬＤＬ＇ｓｒｅｃｅｐｔｏｒｓｏｎｍａｃｒｏｐｈａｇｅ￥ＤｉｎｇＺｈｅｎｈｕａ（丁振华）；ＣｈｅｎＹｕａｎ（陈瑗）；ＺｈｏｕＭｅｉ（周玫）；ＦａｎｇＹｕｎｚｈ...
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Comparative study on the properties of MDA-LDL's and o-LDL's receptors on macrophage |
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| Ding Zhenhua,Chen Yuan,Zhou Mei,Fang Yunzhong. Comparative study on the properties of MDA-LDL's and o-LDL's receptors on macrophage[J]. Journal of Medical Colleges of PLA(China), 1994, 0(3) |
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| Authors: | Ding Zhenhua Chen Yuan Zhou Mei Fang Yunzhong |
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| Abstract: | By means of radioligand binding assay, both receptors of the malondialdehyde modified low density lipoprotein (MDA-LDL) and the oxidatively modified LDL(o-LDL) on the mouse's peritoneal macrophage (MPM) were studied. The results show that there were high affinity receptors for MDA-LDL and o-LDL on the MPM and both receptors had multiplicity of configuration based on the competitive-inhibition curve or parameters IC50 and Ki, and the acetylated LDL (Ac-LDL) and dextran sulfate can both competitively inhibit MDA-LDL or oLDL binding to these receptors in some degree.It is meanful to study the scavenger receptor multiplicity and its relationship to the genesis, protection and treamtent of atherosclerosis. |
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| Keywords: | low density lipoprotein scavenger receptor radioreceptor assay |
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