乌苏里藜芦生物碱单体计米丁的抗动脉血栓作用

[目的]探讨乌苏里藜芦生物碱单体计米丁（germidine）抗动脉血栓形成作用的机制.[方法]大鼠70只,随机分为7组:生理盐水(NS)组、计米丁5个剂量组和阳性对照药物赖氨匹林(LAS)组.测定各组大鼠给药后血流阻塞时间(OT),以NS组为基准,计算不同给药组OT延长百分率.采用Born法评价计米丁的体内、外血小板聚...

Study on anti-arterial thrombosis effect of germidine,an alkaloid isolated from veratrum nigrum L.var ussuriense Nakai

[Objective] To study the effect of germidine against arterial thrombosis in rats as well as the possible mechanism.[Methods] Seventy rats were divided into 7 groups randomly: NS group,5 groups with different doses and positive control group(LAS).Occlusion time(OT) was measured after dosing.Then,the OT increasing percentage of germidine-treated groups,according to OT of saline control group,was served as an index to evaluate anti-arterial thrombosis effects of the drug.Born’s turbidimetric method was used to examine the platelet aggregation inhibitory activity of germidine in vitro and in vivo.Then,60 rats were divided into 6 groups randomly: NS group,4 groups with different doses and LAS group.