非O1/O139群霍乱弧菌:流行、致病因子和耐药

非O1/O139群霍乱弧菌引起的腹泻在许多发展中国家都有发生,其流行涉及到多个血清群。在有些地方,非O1/O139群霍乱弧菌腹泻的发病率甚至超过了O1/O139群霍乱弧菌腹泻的发病率。非O1/O139群霍乱弧菌的致病因子多种多样,肠毒素、蛋白酶、溶血素和三型分泌系统等被认为是重要的致病因子,但其致病机制非常复杂,至今仍然不完全清楚。随着抗生素使用的增加,出现了许多耐药甚至多重耐药菌株。本研究从非O1/O139群霍乱弧菌腹泻的流行情况、致病因子以及耐药方面加以综述。

Vibrio cholerae non-O1/O139:Epidemic,virulence factors and drug resistance

Diarrhea caused by Vibrio cholerae non-O1/O139 occurs frequently in many developing countries, several serogroups are involved the epidemic. In some places, the incidence of diarrhea caused by V. cholerae non-O1/O139 was even higher than that of O1 and O139 serogroups. It is believed that several virulence factors play the important roles in the pathogenicity of V. cholerae non-O1/O139, including enterotoxin, protease, hemolysin and the type three secretion system (TTSS), et al, but its pathogenic mechanism is very complicated and still not fully understood. Meanwhile, drug resistant and even multidrug resistant strains have emerged. This paper summarizes the research progress in the epidemic of diarrhea caused by V. cholerae non-O1/O139, its virulence factors and drug resistance.