肺良恶性结节或肿块CT灌注研究

目的探讨肺内不同良恶性结节或肿块的CT灌注特点,提高鉴别诊断水平。方法回顾性分析了2007年5月至2013年5月入住我院的110例肺部病变患者的临床资料,其中肺癌50例,肺良性肿物60例。应用PHILIPS BRILLIANCE 16层螺旋CT对上述两组患者肺部进行扫描,并使用CT灌注软件包一般灌注模式进行分析,对两组病变的灌注值(PV)、血容积(BV)、最高强化值(PEI)以及达峰时间(TTP)进行测定与记录。结果 (1)高、中分化肺癌组(n=24)与低、未分化肺癌组(n=26)PV、PEI及BV值相比,差异均具有统计学意义(P0.05,P0.01),但两组TTP无统计学差异(P0.05);(2)肺良性肿物组(n=60)与肺癌组(n=50)PV及PEI相比,差异均具有统计学意义(P0.05),但两组BV及TTP相比,差异无统计学意义(P0.05);(3)肺鳞癌组(n=28)与肺腺癌组(n=22)PV、PEI、BV及TTP相比,差异均无统计学意义(P0.05)。结论 16层螺旋CT灌注成像能够定量地反映肺内肿块血供特点的相关信息,有利于肺癌与肺内良性结节或肿块的鉴别诊断的鉴别诊断具有较高的价值,值得推广并应用。

Analysis of 16-Slice Spiral CT Perfusion Imaging in Lung Cancer and Benign Lung Tumor Differential Diagnosis Value

Objective To Explore different benign and malignant pulmonary nodules or masses on CT perfusion characteristics, improve the level of differential diagnosis. Methods 110 cases of patients with lung diseases were retrospectively analyzed from May 2007 to May 2013 in our hospital, of whom were 50 cases of patients with lung cancer and 60 cases of patients with benign lung tumor. The two groups of patients lungs were scanned by applying PHILIPS BRILLIANCE 16-slice spiral CT and general of perfusion were analyzed by using CT perfusion pattern software package, and lesions perfusion values （PV）, blood volume （BV）, maximum enhancement value （PEI） and the time to peak （TTP） were measured and recorded. Results （1） There was statistically significant of PV, PEI and BV values between the highly-differentiated lung cancer group （n=24） and low, undifferentiated lung cancer group （n=26）, but there was no significant difference of TTP between the two groups （P〉0.05）. （2） The differences of PV and PEI value were statistically significant between benign lung tumor group （n=60） and lung cancer （n=50） （P0.05）; （3） squamous cell carcinoma group （n=28） and lung adenocarcinoma （n=22） PV, PEI , BV and TTP, the difference was not statistically significant （P〉0.05）;（4） central lung cancer group （n=21） and peripheral lung cancer group （n=29） PV, PEI, BV and TTP compared the difference was not statistically significant （P〉0.05）. Conclusion 16-slice spiral CT perfusion imaging can quantitatively reflect lung tumor blood supply relevant information, in favor of lung cancer and benign pulmonary nodules or lumps in the differential diagnosis in the differential diagnosis of higher value, worthy of promotion and application.