Interaction between capsaicin and nitrate tolerance in isolated guinea-pig heart |
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| Authors: | Oroszi G Szilvassy Z Nemeth J Ferdinandy P Szolcsanyi J Tosaki A |
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| Affiliation: | Department of Pharmacology and Pharmacotherapy, Medical University of Pecs, Hungary. oroszi@apacs.pote.hu |
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| Abstract: | Capsaicin-induced increases in heart rate and coronary flow were blocked by N(G)-nitro-L-Arg-methyl ester (30 mM) in Langendorff-perfused guinea-pig hearts. Neither heart rate nor coronary flow changed by capsaicin in hearts from animals made tolerant to the hypotensive effect of 30 microg/kg nitroglycerin by the administration of 50 mg/kg nitroglycerin subcutaneously 4 times a day over 3 days. We conclude that the effector function of sensory nerves may deteriorate in nitrate tolerance. |
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