| 高效液相色谱法测定复方盐酸麻黄碱滴眼液中盐酸麻黄碱的含量 |
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| 引用本文： | 陆蕴,余菁.高效液相色谱法测定复方盐酸麻黄碱滴眼液中盐酸麻黄碱的含量[J].中国药房,2006,17(12):939-940. |
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| 作者姓名： | 陆蕴 余菁 |
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| 作者单位： | 1. 杭州市第一人民医院,杭州市,310006
2. 杭州市药品检验所,杭州市,310014 |
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| 摘 要： | 目的建立以高效液相色谱法测定复方盐酸麻黄碱滴眼液中盐酸麻黄碱含量的方法。方法色谱柱为C18,流动相为乙腈-0.2%磷酸溶液(3∶97),流速为1.0ml/min,检测波长为210nm,柱温为40℃。结果盐酸麻黄碱进样量在0.06μg~0.96μg范围内与峰面积积分值线性关系良好(r=1.0000),平均回收率为99.87%(RSD=0.63%)。结论本方法简便、快速、准确,可用于复方盐酸麻黄碱滴眼液的质量控制。
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| 关 键 词： | 高效液相色谱法 复方盐酸麻黄碱滴眼液 盐酸麻黄碱 含量 |
| 文章编号： | 1001-0408(2006)12-0939-02 |
| 收稿时间： | 03 27 2006 12:00AM |
| 修稿时间： | 05 3 2006 12:00AM |
Content Determination of Ephedrine Hydrochloride in Compound Ephedrine Hydrochloride Eye Drops by HPLC |
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| LU Yun,YU Jing.Content Determination of Ephedrine Hydrochloride in Compound Ephedrine Hydrochloride Eye Drops by HPLC[J].China Pharmacy,2006,17(12):939-940. |
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| Authors: | LU Yun YU Jing |
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| Abstract: | OBJECTIVE:To establish an HPLC method for determination of ephedrine hydrochloride in compound ephedr_ine hydrochloride eye drops.METHODS:The separation was performed on C18,the mobile phase was consisted of acetonitrile-0.2% phosphate solution(3∶97) with a flow speed at 1.0ml/min and detection wavelength at 210nm,the column temperature was 40℃.RESULTS:Ephedrine hydrochloride was in the good linear range when the sample size was between 0.06μg～0.96μg(r=1.0 000);the average recovery rate was 99.87%(RSD=0.63%).CONCLUSIONS:The methode was simple,rapid and accurate,which can be applied to quality control of compound ephedrine hydrochloride eye drops. |
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| Keywords: | HPLC Compound ephedrine hydrochloride eye drops Ephedrine hydrochloride Content |
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