子宫颈病变2015例与高危型HPV感染情况分析

目的:分析2 015例不同类型子宫颈病变患者高危型人乳头瘤病毒(HPV)的感染情况,探讨高危型HPV感染与子宫颈病变的关系。方法:采用美国Digene公司杂交捕获仪(HC2)检测2 015例不同类型子宫颈病变患者的13种高危型HPV病毒的感染情况,结合病理诊断进行分析。结果:2 015例子宫颈病变患者中,子宫颈炎1 371例,宫颈上皮内瘤变(CIN)644例,其中CIN 352例,CIN 194例,CIN 98例,其13种高危型HPV病毒的感染率分别是28.0%、58.8%、89.7%、94.9%,中高度CIN(CIN、CIN)感染率明显高于低度CIN和宫颈炎(P<0.05)。结论:子宫颈病变的发生、发展与高危型HPV感染有关,随着病变程度的加重,高危型HPV感染率明显增高,高危型HPV检测可用于子宫颈癌和癌前病变的筛查及治疗后的随访。

The analysis on the infection of high risk type of HPV in cervical lesion of 2015 cases

Objective：To study the relationship between the infection of high risk type of human papilloma virus（HPV） through the infection status of 2015 cases with cervical lesion.Methods：Hybrid Capture Ⅱ Assay（HC2） which could identify 13 high risk HPV was used to confirm cervical infection of HPV in cervical lesion of 2015 cases,the results were analyzed by pathologic diagnosis.Results：There were 1371 cases with chronic cervicitis,352cases with cervical intra-epithelial（CIN）Ⅰ,194 cases with CIN Ⅱ,98 Cases with CINⅢ,and the rates of infection of high risk type of HPV were 28.0%,58.8%,89.7%,94.9% respectively.The infection rates of HPV of the cases with CIN Ⅱ and CIN Ⅲ were higher than that in the cases with CINⅠand chronic cervicitis（P0.05）.Conclusion：The examination of high risk type of HPV could be applied to screen the cervical cancer,cervical intra-epithelial neoplasia and also to follow-up the cases post-treatment.