急性髓系白血病患者化疗前口腔治疗预防化疗性口腔黏膜炎的初步研究

目的探讨急性髓系白血病患者化疗前给予口腔治疗对化疗期间口腔黏膜炎发生率及炎症程度的影响，为临床造血系统恶性肿瘤患者化疗前口腔治疗效果提供初步依据。 方法74例患有急性髓系白血病的患者根据患者是否愿意化疗前接受口腔治疗，分为口腔治疗+化疗组和化疗组，口腔治疗+化疗组在化疗前给予全面的口腔检查以及对存在问题进行处理，化疗组则不给予任何口腔治疗。评价和记录口腔黏膜炎的发生率及程度。采用卡方检验及Mann-Whitney U检验，比较两组间差异。 结果口腔治疗+化疗组的口腔黏膜炎发生率要小于化疗组(χ²=5.659，P=0.017)，炎症程度也低于化疗组(U=0，P=0)。 结论化疗前口腔治疗有利于减低急性髓系细胞患者化疗期间口腔黏膜炎的发生率，减轻口腔黏膜炎的炎症程度，具有重要的临床意义。

Preliminary study on the effect of oral treatments of patients with acute myeloid leukemia before chemotherapy

ObjectiveTo observed the effect of oral treatments before chemotherapy on the incidence and the degree of inflammation of oral mucositis of patients with acute myeloid leukemia (AML)during the chemotherapeutic period. Provide preliminary evidence for clinical effect of oral intervention before chemotherapy on patients with hematopoietic system malignant tumor. MethodsSeventy-four patients with AML were divided into two groups depend on whether they want to receive oral treatments before chemotherapy. Oral treatments plus chemotherapy group received comprehensive oral examinations and treatments prechemotherapy. The chemotherapy group was not given any oral treatment. Evaluated and recorded the incidence and degree of oral mucositis. Chi square test and Mann-Whitney U were used to compare the difference between the two groups. ResultsThe incidence of oral mucositis of the oral treatments plus chemotherapy group was less than the chemotherapy group(χ²=5.659, P=0.017), the degree of inflammation was also lower than that of the chemotherapy group(U=0, P=0). ConclusionOral treatments before chemotherapy can reduce the incidence and the degree of inflammation of oral mucositis of patients with AML during the chemotherapeutic period. It has important clinical significance.