新一代测序技术在肿瘤精准医学中的应用

精准医学依据全基因组测序数据及其他相关分子信息与个人疾病状态资料,可更好地诠释疾病发生的分子机理,进而为开发靶向药物和实现精准用药做准备。目前,精准医学的理念将首先在临床肿瘤诊治中应用,人们可根据导致疾病的潜在分子和相关因子对疾病进行诊断和分类,实现"同病异治"和"异病同治"的临床治疗策略。此外,新一代测序技术也将成为临床肿瘤诊治中的不可或缺的技术;同时,还需进一步完善相应的管理政策,以达到临床应用规范化管理的目的。

Application of next generation sequencing in cancer precision medicine

In precision medicine. whole genome sequencing data, related molecular information and individual clinical data, are often employed forselecting appropriate and optmal therepiesbased on the contect of a patient′s genetic conten, and then prepare for the development of targeted drugs and achieve accurate medical care. At present, the concept of precision medicine is infiltrating into the fields of clinical tumor diagnosis and treatment. Tumor will be diagnosed and classified according to underlying molecular and related factors to achieve "treating the same disease with different governance" and "treating different diseases with the same protocol". In addition, the next generation sequencing(NGS) technology will be an indispensable technology in precision medicine, which promotes the application of precision medical treatment in the clinical setting. Mereover, it also need to improve the regulatory policies, to achieve the goal of standardized management of NGS in clinical application.