妊娠与代谢综合征的关系

代谢综合征(MetS)是多重代谢异常聚集的现象，主要包括肥胖、血糖调节异常、高血压和血脂异常。胰岛素抵抗(IR)可能是导致MetS的主要病理、生理机制。孕前存在MetS的孕妇于孕期发生妊娠并发症，如妊娠期糖尿病(GDM)、妊娠期高血压疾病(HDCP)的风险增加。同时，GDM与HDCP孕妇产后罹患代谢性疾病的风险也高于正常妊娠孕妇。新生儿出生体质量与其远期发生代谢性疾病，亦有一定的关系。笔者拟就妊娠与MetS的关系进行综述如下。

Relationship between pregnancy and metabolic syndrome

Metabolic syndrome (MetS) refers to a cluster of metabolic abnormalities, including obesity, hyperglycemia, hypertension and dyslipidemia. Insulin resistance (IR) is a central feature in the pathogens of MetS. Women with pre-pregnancy metabolic disorders are at increased risk of developing gestational diabetes mellitus (GDM) and hypertensive disorder complicated pregnancy (HDCP), as well as developing MetS after delivery. Birth weight of newborn plays a certain role in the long-term metabolic disorders. This paper reviews the relationship between MetS and pregnancy as follows.