凝血因子Ⅺ缺陷症导致拔牙后出血1例报告

凝血因子Ⅺ(factor Ⅺ,FⅪ)缺陷症是一种遗传性出血病。FⅪ缺乏可引起凝血酶缺乏、纤溶亢进,从而引起出血增多。FⅪ缺陷症患者出血多发生于口腔、鼻腔黏膜等纤溶活性较高的部位,出血常与创伤及手术有关。本文报告1例中日友好医院近期诊治的病例,患者拔牙术后术区反复出血,给予碘仿砂条填塞方法止血控制病情,最终血液检查确诊患者罹患凝血因子Ⅺ缺陷症,通过血浆输入治疗,最终止血成功。

Hemorrhage after tooth extraction due to coagulation factor Ⅺ deficiency: a case report

Coagulation factor Ⅺ(factor Ⅺ,FⅪ)deficiency is a kind of hereditary hemorrhagic disease. Lack of FⅪ can cause lack of thrombin and high fibrinolytic activity, which leads to increased bleeding. Bleeding always happens in oral and nasal mucosa with high fibrinolytic activity in patients, and is often associated with trauma and surgery. This paper reported a case treated in China-Japan Friendship Hospital. The patient bled repeatedly after tooth extraction and was controlled with insertion of a tela iodoformum. The final diagnosis of the patient was coagulation factor Ⅺ deficiency and the bleeding was eventually stopped by plasma input.