右美托嘧啶联合曲马多预防瑞芬太尼麻醉后痛觉过敏的疗效观察

目的探讨右美托嘧啶联合曲马多预防瑞芬太尼麻醉后痛觉过敏的临床效果。方法选取我院行全麻手术的患者60例,随机分为观察组和对照组,每组30例。观察组患者采用右美托嘧啶和曲马多联合应用,对照组患者单独应用曲马多,分别记录患者术后20 min、40 min、60 min时心率、平均动脉压、镇静程度评分、VAS评分、不良反应发生情况及发生率。结果观察组患者术后40 min、60 min时的HR、MAP、VAS评分及不良反应发生率均明显低于对照组患者,镇静程度评分明显高于对照组患者,差异具有统计学意义,P＜0.05。结论综上所述,右美托嘧啶联合曲马多能够有效预防瑞芬太尼麻醉后出现痛觉过敏现象,并降低术后不良反应发生率,为临床应用提供参考。

The clinical analysis of dexmedetomidine combined tramadol for remifentanil-induced hyperalgesia

Objective To investigate the clinical effects of dexmedetomidine combined with tramadol in prevention of remifentanil-induced hyperalgesia.Methods All of patients had general anesthesia in our hospital were divided into observation group and control group randomly,each group was 30 patients.The observation group were given tramadol combined with dexmedetomidine,while the control group were given only tramadol.HR,MAP,scores of degree of sedation at instance and VAS at minutes 20、40、60 after operationwere recorded,and postoperative adverse reaction ratewere observed.Results The HR,MAP and VAS were lower in observation group than that in control group at minutes 40、60 after operation,while the scores of degree of sedation at instance was higher in observation group than that in control group at minutes 40、60 after operation,the difference was statistically significant(P＜0.05).The postoperative adverse reaction rate was lower in observation group than that in control group.Conclusion Dexmedetomidine combined with tramadol can effectively prevent remifentanil-induced hyperalgesia,and reduce the occurrence of postoperative complications.