S100阳性不典型幼年性黄色肉芽肿一例随访观察并文献复习

【摘要】 患者男，3岁，因躯干多发棕黄色丘疹3个月就诊。皮损组织病理学检查，见真皮较多单一核组织细胞、嗜酸性粒细胞及少量淋巴细胞浸润。免疫组化示S100阳性、CD1a部分阳性、CD68阳性。其后原发皮疹颜色渐变暗，部分变平消退，留色素沉着，但仍有新发皮疹。4个月后第2次组织病理学检查显示，除组织细胞、嗜酸性粒细胞外，真皮尚可见少许多核巨细胞。免疫组化示组织细胞S100阴性、CD1a阴性、CD68 阳性。诊断：幼年性黄色肉芽肿。

A case of S100-positive atypical juvenile xanthogranuloma: a longitudinal observation and review of the literature

Wang Yanhong, Shen Hong, Xu Aie. Department of Dermatology, Third People′s Hospital of Hangzhou, Hangzhou 310009, China Corresponding anthor: Shen Hong, Email: shenhongsh@medmail.com.cn 【Abstract】 A 3-year-old boy presented with a 3-month history of brown-yellow papules scattered on the trunk. The first skin biopsy showed a dermal infiltrate of many mononuclear histiocytes, eosinophilic granulocytes and a small number of lymphocytes. Immunohistochemical examination of the lesions demonstrated positive reactions with anti-CD68, -S100 and -CD1a （partial） antibodies. After the biopsy, the skin lesions gradually turned dark and partially regressed leaving hyperpigmentation, but new lesions continuously appeared. Four months later, a second biopsy was performed, and showed a dermal infiltrate of histiocytes with eosinophilic granulocytes and a few multinucleated giant cells. Immunohistochemistry showed that the histiocytes stained positive for CD68, but negative for S100 and CD1a. Based on the above findings, the patient was diagnosed with juvenile xanthogranuloma.