平均血小板容积与糖尿病视网膜病变严重程度的横断面研究

目的　评估平均血小板容积（ｍｅａｎｐｌａｔｅｌｅｔｖｏｌｕｍｅ，ＭＰＶ）与糖尿病视网膜病变（ｄｉａｂｅｔｉｃｒｅｔｉｎｏｐａｔｈｙ，ＤＲ）严重程度的关系。方法　横断面研究。选取所有于２０１２年１月至２０１３年１２月在我院眼科中心住院的ＤＲ患者１３７例（非增殖期６７例，增殖期７０例），同时选取７２例无ＤＲ糖尿病患者和７０例无糖尿病健康人群进行对照。收集人口学资料及疾病史，抽空腹血行ＭＰＶ和血小板计数等检查。结果　健康对照组人群ＭＰＶ水平［７．２（５．６－９．９）ｆＬ］显著低于糖尿病各组（均为Ｐ＜０．０５），且随ＤＲ病变分级的增加，ＭＰＶ水平显著增加，分别为７．８（５．７－１０．１）ｆＬ、８．３（５．５－１１．０）ｆＬ和８．９（５．９－１２．５）ｆＬ，差异均有统计学意义（均为Ｐ＜０．０５）。Ｌｏｇｉｓｔｉｃ回归分析显示，随着ＭＰＶ水平升高，非增殖期（ＯＲ:１．３８２；９５％ＣＩ:１．２８０－１．４８４）和增殖期ＤＲ（ＯＲ:１４８１；９５％ＣＩ:１．３７０－１．５９２）的患病风险显著增加（均为Ｐ＜０．００１）。结论　ＭＰＶ水平随ＤＲ严重程度增加而升高；随着ＭＰＶ水平升高，非增殖期和增殖期ＤＲ患病风险增加。

Relationship between mean platelet volume and development of diabetic retinopathy: a cross-sectional study

Objective To access the relationship between mean platelet volume ( MPV) and development of diabetic retinopathy ( DR) . Methods The cross-sectional survey included 137 consecutive patients with DR ( 67 with non-proliferative and 70 with proliferative DR ) in our hospital during January 2012 and December 2013. Another 72 diabetic patients without DR and 70 healthy volunteers were matched as controls. Demographic data and disease history were gained. Fasting blood sample was collected to measure MPV and platelet count. Results Compared with healthy controls 7. 2 (5. 6 - 9. 9) fL ] , a significant difference was found in MPV values among diabetic patients( all P < 0. 05 ) . The higher development of DR corresponded with a sigruficantly higher level of MPV 7. 8 (5. 7 - 10. I ) fL,8. 3 (5. 5 - 11. 0) fL and 8. 9 (5. 9 - 12. 5 ) fL for patients without DR , non-proliferative DR and proliferative DR , respectively ] . Logistic analysis showed that there were significant increased risks in the prevalence of non-proliferative ( OR : 1. 382 ;95% C/: 1. 280 - 1. 484 ) and proliferative DR ( OR : 1. 481 ; 95% C/: 1. 370 - 1. 592) with the increased MPV value ( all P < 0. 001) . Conclusion The MPV value is parallel with the development of DR . and there is increased risk of non-proliferative and proliferative DR with the MPV value increases.