区域动脉灌注血必净注射液治疗重症急性胰腺炎疗效观察

目的 评价胰腺局部动脉置管持续灌注血必净治疗重症急性胰腺炎的疗效.方法 将37例重症急性胰腺炎患者分为A组(21例)和B组(16),A组在确诊后立即行动脉介入,采用Seldinger法置导管于胰腺病变供血动脉,持续灌注血必净注射液(天津红日药业股份有限公司生产)100 ml,2次/d,头孢他啶2 g,3次/d,连续7 d;B组患者静脉滴注血必净注射液,100 ml,2次/d,头孢他啶2 g,3次/d,连续7 d.比较两组患者腹痛缓解时间、肠道功能恢复时间、撤离呼吸机时间、急性生理慢性健康评分(APACHE-Ⅱ评分)及血清肿瘤坏死因子-α(TNF-α)、白介素6(IL-6)水平.结果 治疗后A组患者腹痛缓解时间、肠道功能恢复时间、撤离呼吸机时间显著短于B组,败血症发生率及中转开腹率显著低于B组,差异有统计学意义(P＜0.05).治疗第7天、第14天A组患者APACHE-Ⅱ评分显著低于B组,差异有统计学意义(P＜0.05);治疗第3天、第7天A组患者血清TNF-α、IL-6水平亦显著低于B组,差异有统计学意义(P＜0.05).结论 胰腺局部动脉置管持续灌注血必净注射液治疗重症急性胰腺炎较静脉用药疗效更好,且并发症少.

Xuebijing Regional Arterial Infusion in Treatment of Severe Acute Pancreatitis

Objective To evaluate the efficacy of continuous Xuebijing regional arterial infusion through catheters in treatment of severe acute pancreatitis(SAP).Methods Thirty-seven SAP patients were divided into groups A and B.Group A were given immediate arterial intervention after conformed diagnoses,using Seldinger method to placing a catheter in the lesioned pancreas artery and continuously infusing Xuebijing injection(100 ml,twice/d) and ceftazidime(2 g,3 times/d,continuously for 7 d).Alleviation time of abdomi...