螺旋藻多糖对臭氧致小鼠肺损伤的保护性研究

目的　观察臭氧对肺造成的损伤和螺旋藻多糖(polysaccharidefromspirulinaplatensis ,PSP)对损伤的影响。方法　利用臭氧吸入造成肺损伤模型 ,以黄嘌呤氧化酶法测定血清和肺匀浆的SOD活性 ,硫代巴比妥显色法测定MDA含量 ,并利用透射电镜观察肺组织细胞的形态学变化。结果　各PSP给药组的小鼠 ,血清和肺组织的SOD活性上升 ,MDA含量降低 ,与模型组相比 ,在统计学上差异有显著性(P <0 0 5 )。电镜结果发现模型组的肺组织细胞有明显的凋亡性改变 ,而各给药组的损伤相对较轻。结论　PSP可以保护臭氧造成的肺损伤

Protective effect of polysaccharide from spirulina platensis on injured lung induced by ozone

AIM To observe the effect of polysaccharide from spirulina platensis(PSP) on lung injured by exposing ozone. METHODS The injury model of lung were induced by exposing ozone. The xanthine oxidase method and TBA were used to determine SOD and MDA in serum and lung respectively. The transmission electron microscope was used to observe the structural change of lung cell. RESULTS Compared with model mice, SOD in the groups of PSP administrated mice were increased and MDA were decreased significantly(P<0 05). The morphology indicated the cell showed apoptosis in model mice. CONCLUSION PSP has protective effect in injury lung induced by ozone.