| 拉米夫定联合清肝解毒汤对肝郁脾虚型慢性乙型肝炎多聚酶基因变异的影响 |
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| 引用本文： | 景博琼,王宏峰,徐菲莉. 拉米夫定联合清肝解毒汤对肝郁脾虚型慢性乙型肝炎多聚酶基因变异的影响[J]. 地方病通报, 2010, 25(2): 20-22 |
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| 作者姓名： | 景博琼 王宏峰 徐菲莉 |
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| 作者单位： | 新疆医科大学,乌鲁木齐,830054;新疆医科大学附属中医医院,乌鲁木齐,830000 |
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| 摘 要： | 目的观察拉米夫定联合清肝解毒汤治疗肝郁脾虚型慢性乙型肝炎患者对HBVYMDD变异的影响。方法将74例未间断服用拉米夫定治疗1年的未发生YMDD变异的慢性乙型肝炎患者分为对照组34例,治疗组40例,治疗组给予拉米夫定联合清肝解毒汤治疗、对照组给予单独服用拉米夫定治疗,治疗6个月,观察患者YMDD变异、ALT水平的变化。结果治疗3个月后,治疗组YMDD变异发生率为8%,对照组YMDD变异发生率为25%,两组比较,差异无统计学意义（P〉0.05）;治疗6个月后,治疗组治疗YMDD变异发生率为14%,对照组YMDD变异发生率为37%,两组比较,差异有统计学意义（P〈0.05）;治疗组与对照组血清丙氨酸氨基转移酶比较,差异无统计学意义（F=0.238,P〉0.05）;治疗前后血清丙氨酸氨基转移酶比较,差异无统计学意义（F=0.185,P〉0.05）。结论清肝解毒汤联合拉米夫定可减少HBVYMDD变异的发生。
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| 关 键 词： | 慢性乙型肝炎 YMDD变异 拉米夫定 清肝解毒汤 |
Effect of Lamivudine in Combination with Qingganjiedutang on Pol Gene Mutation in Patients with Chronic Hepatitis B of Stagnation of Liver-Qi with Spleen Deficiency |
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| JING Bo-qiong,WANG Hong-feng,XU Fei-li. Effect of Lamivudine in Combination with Qingganjiedutang on Pol Gene Mutation in Patients with Chronic Hepatitis B of Stagnation of Liver-Qi with Spleen Deficiency[J]. Endemic Diseases Bulletin, 2010, 25(2): 20-22 |
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| Authors: | JING Bo-qiong WANG Hong-feng XU Fei-li |
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| Affiliation: | JING Bo-qiong1,WANG Hong-feng2,XU Fei-li2(1. Xinjiang Medical University,Urumqi,Xinjiang 830054,China,2. Affiliated Hospital of Traditional Chinese Medicine,Xinjiang Medical University,Xinjiang 830000,China) |
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| Abstract: | Objective To observe effect of Lamivudine in combination with Qingganjiedutang on pol gene mutation (YMDD) in patients with chronic hepatitis B of stagnation of liver-qi with spleen deficiency. Methods Seventy-four cases with chronic hepatitis B treated by Lamivudine for one year without YMDD mutation were randomly divided into 2 groups, including 40 cases of treated group and 34 cases of control group. The treated group was administered with Lamivudine in combination with Qingganjiedutang for 6 months, whi... |
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| Keywords: | Chronic hepatitis B YMDD mutation Lamivudine Qingganjiedutang |
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