心功能不全患者血浆N-末端脑钠肽前体及血清尿酸浓度的相关性

目的：探讨慢性充血性心力衰竭（CHF）患者血浆N-末端脑钠肽前体（NT—proBNP）浓度及血清尿酸（UA）浓度变化及其相关性。方法：65例心功能不全患者，按左室射血分数（LVEF）分两组，即LVEF〉40％组（32例），LVEF≤40％组（33例）；30例健康体检者作为正常对照组。所有入选者人院后常规检查NT—proBNP，UA，超声心动图测定LVEF。结果：LVEF≤40％组NT—proBNP1102．3（276．34，1483．3）pg／ml]和UAE478．0（351．5．576．7）μmol／L]水平较LVEF〉40％组91．5（22．07。165．6）pg／ml；344．7（264．6，424．6）μmol／L]和正常对照组14．6（5．4，54．1）pg／ml；289．7（214．6，326．3）μmol／L]显著升高．P均〈0．01；LVEF〉40％组NT～proBNP水平显著高于正常对照组（P〈0．01），UA水平差异无显著性（P〉0．05）；心功能不全患者NT—proBNP与UA呈正相关（r为0．46，P％0．01）；LVEF与NT—proBNP和uA均呈负相关（r=-0．63、-0．42，P均〈0．01）。结论：慢性充血性心力衰竭患者血NT—proBNP浓度和UA浓度升高，且两者呈正相关。测定NT—proBNP和UA浓度有助于判断病情，早期治疗，改善预后。

Correlation between plasma level of N-terminal ProB-type natriuretic peptide and serum uric acid in patients with congestive heart failure

Objective： To investigate the clinical significances of changes of plasma level of N--terminal ProB--type natriuretic peptide （NT--proBNP） and serum uric acid （UA） in patients with congestive heart failure （CHF）, and correlation between UA and NT--proBNP in CHF patients. Methods： A total of 65 CHF patients were enrolled in this study, including 32 cases whose left ventricular ejection fraction （LVEF） was 〉 40% （LVEF〉40% group） and 33 cases whose LVEF were≤40% （LVEF≤40% group）. The 30 healthy persons were selected as normal control. The plasma NT-proBNP, UA concentrations and LVEF of all case were measured. Results： The plasma levels of NT- proBNP and UA were 1102.3 （276.34, 1483.3） pg/ml and 478.0 （351.5, 576.7） μmol L] in LVEF≤40% group, these were more than those of LVEF 〉 40% group 91.5 （22.07, 165.6） pg/ml , 344.7 （264.6, 424.6） μmoL L], P〈0.01 all , and normal control group 14.6 （5.4, 54.1） pg/ml and 289.7 （214.6, 326.3） μmol/ L] P〈0.01 all , respectively. There was no significant difference in level of UA in LVEF〉 40% group and control group （P〉0.05）. NT--proBNP level was positively correlated with UA in CHF （r=0.46, P〈0.01） ; NT--proBNP level and UA level were negatively correlated with LVEF （r= -0.63, --0.42, P〈0.01 all）. Conclusion.. The plasma NT--ProBNP level and UA level in CHF is increased and positively correlated with each other; Measuring the plasma NT--proBNP and UA is useful to find the patients with CHF at the high risk, for receive the early intervention, and improve prognosis.