| 涂圈压电传感器提取频移法测定微量麻黄碱及其在制剂分析中的应用 |
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| 引用本文： | 聂利华,张小腾,姚守拙.涂圈压电传感器提取频移法测定微量麻黄碱及其在制剂分析中的应用[J].药学学报,1991,26(4):311-314. |
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| 作者姓名： | 聂利华 张小腾 姚守拙 |
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| 作者单位： | 湖南大学化工系新材料研究所，湖南大学化工系新材料研究所，湖南大学化工系新材料研究所 长沙 410082，长沙 410082，长沙 410082 |
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| 基金项目： | 国家自然科学基金，国家教委博士点基金 |
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| 摘 要： | 麻黄碱在受热时可挥发,在蒸除提取溶剂时相随挥发损失,不能用常规的提取重量法测定。使用本室新近研制的涂圈压电传感器作为超微量质量敏感元件,取常规提取重量法的基本原理,并加以改进,可以实现麻黄碱的快速分析,从而扩大该经典方法的应用范围。本法可测定低至亚μg级的麻黄碱,具有方法简便、灵敏度高等优点。
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| 关 键 词： | 提取频移法 压电传感器 麻黄碱 |
| 收稿时间： | 1990-01-12 |
USE OF EXTRACTION-FREQUENCYMETRIC METHOD FOR THE DETERMINATION OF MICROQUANTITIES OF EPHEDRINE AND ITS APPLICATION IN PHARMACEUTICAL ANALYSIS |
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| LH Nie,XT Zhang and SZ Yao.USE OF EXTRACTION-FREQUENCYMETRIC METHOD FOR THE DETERMINATION OF MICROQUANTITIES OF EPHEDRINE AND ITS APPLICATION IN PHARMACEUTICAL ANALYSIS[J].Acta Pharmaceutica Sinica,1991,26(4):311-314. |
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| Authors: | LH Nie XT Zhang and SZ Yao |
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| Institution: | Chemical Engineering Department, Hunan University, Changsha. |
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| Abstract: | A new extraction--frequency metric method has been proposed for the determination of ephedrine, which can not be determined by the conventional extraction--weighing method due to its volatility. The method is based on extraction of the free alkaloid followed by measuring the frequency shift of a specially constructed ring--coated piezoelectric crystal at room temperature. The frequency shift is in linear relationship with the content of ephedrine hydrochloride over a range 0.05-1.2 micrograms with a correlation coefficient of 0.999 and a detection limit of 0.02 micrograms. Methods for the assay of ephedrine hydrochloride tablet and nasal solution have been proposed. |
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| Keywords: | Extraction-frequencymetric method Piezoelectric detector Ephedrine |
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