| 栀子总苷对阿司匹林致胃黏膜损伤的保护作用 |
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| 引用本文： | 马燕,金家宏,赵维中,徐以亮.栀子总苷对阿司匹林致胃黏膜损伤的保护作用[J].安徽医科大学学报,2004,39(5):354-356. |
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| 作者姓名： | 马燕 金家宏 赵维中 徐以亮 |
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| 作者单位： | 安徽医科大学药理学教研室,合肥,230032;安徽中医学院2000级实习生;江苏江阴天江药业有限公司,江阴,214434 |
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| 摘 要： | 目的研究栀子总苷(TGZ)对阿司匹林所致急性胃黏膜损伤(AGML)的保护作用.方法采用阿司匹林ig诱导大鼠AGML模型.观察TGZ 140、70、35 mg/kg 3个剂量组和对照组的AGML指数,并同时检测胃黏膜局部血流量(GMBF)及血浆超氧化物歧化酶(SOD)活性和丙二醛(MDA)含量. 结果 TGZ用药组的AGML指数较模型对照组显著降低,GMBF较模型对照组明显增加;TGZ可明显提高血浆中SOD活性,降低其MDA含量.结论 TGZ 对阿司匹林所致AGML有明显的保护作用,其作用机制可能与增加胃黏膜血流及抗氧化作用有关.
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| 关 键 词： | 阿司匹林/副作用 胃黏膜/病理学 栀子/药理学 大鼠 |
| 文章编号： | 1000-1492(2004)05-0354-03 |
| 修稿时间： | 2004年3月26日 |
Protective effect of total glycosides of Zhizi on experimental acute gastric mucosal lesion induced by aspirin |
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| Ma Yan,Jin Jiahong,Zhao Weizhong et al.Protective effect of total glycosides of Zhizi on experimental acute gastric mucosal lesion induced by aspirin[J].Acta Universitis Medicinalis Anhui,2004,39(5):354-356. |
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| Authors: | Ma Yan Jin Jiahong Zhao Weizhong |
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| Abstract: | Objective To study the protective effect of total glycosides of Zhizi (TGZ) on experimental acute gastric mucosal lesion induced by aspirin in rats.Methods We used aspirin intragastric injection to make the model of acute gastric mucosal lesion (AGML) , measured the lesion index of rats in TGZ (140,70,35 mg/kg) and control groups. The activity of superoxide dismutase (SOD) and Malonyl dialdehyde (MDA) level in blood and gastric mucosal blood flow (GMBF) were determined as well.Results Gastric mucosal lesion index of all the TGZ dosage groups was obviously reduced as compared with the control group. GMBF was significantly increased. TGZ increased SOD activity but reduced MDA content. Conclusion TGZ can inhibit aspirin-induced gastric mucosal lesion, the mechanism may be related to increase GMBF and antioxidation. |
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| Keywords: | aspirin/adverse effects gastric mucosa/pathology gardenia jasminoides/pharmacology rats |
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