葛根素与复方丹参注射液联用对急性高血压脑出血患者神经功能的改善作用

目的:探讨葛根素与复方丹参注射液联用对急性高血压脑出血患者神经功能的改善作用.方法:200例急性高血压脑出血患者随机分为对照组、葛根素组、复方丹参组和联合治疗组,每组50例.对照组采用西医常规治疗,葛根素组是在西医常规治疗基础上加用葛根素注射液治疗,复方丹参组是在西医常规治疗基础上加用复方丹参注射液治疗,联合治疗组是在西医常规治疗基础上加用葛根素和复方丹参注射液联合治疗,每组均连续给药2周.计算血肿体积和脑水肿程度,检测血浆D-二聚体和C-反应蛋白浓度,记录美国国立卫生院神经功能缺损评分和Barthel评分.结果:经析因设计方差分析,治疗后第14天,联合治疗组血肿体积和脑水肿程度均显著低于另外3组(均P＜0.05),治疗后第7天和第14天,联合治疗组血浆D-二聚体和C-反应蛋白浓度均显著低于另外3组(均P＜0.05)；治疗后3个月,联合治疗组美国国立卫生院神经功能缺损评分均显著小于另外3组(均P＜0.05),联合治疗组Barthel评分均显著大于另外3组(均P＜0.05).结论:复方丹参注射液和葛根素之间有正性协同作用,联合应用可以更好地促进急性高血压脑出血患者的神经功能恢复.

Effect of puerarin combined with compound salvia injection on neurological function of patients with acute hypertensive intracerebral hemorrhage

AIM: To investigate the interventional effect of puerarin combined with compound salvia injection on neurological function of patients with acute hypertensive intracerebral hemorrhage.METHODS: Two hundred patients with acute hypertensive intracerebral hemorrhage were randomly divided into control group,puerarin group,compound salvia group and combined treatment group.Control group received ordinary therapy,puerarin group received additional puerarin injection based on ordinary therapy,compound salvia group received additional compound salvia injection based on ordinary therapy and combined treatment group received additional puerarin and compound salvia injection based on ordinary therapy.Each group had been treated continuously for two weeks.Hematoma volume and brain edema index were calculated.Plasma C-reactive protein and D-dimer concentrations were measured.And National Institutes of Health Stroke Scale score and Barthel score were recorded.RESULTS:Using analysis of variance for factorial design,hematoma volume and brain edema index in combined treatment group were markedly lower than those in other three groups at day 14 post-treatment(all P<0.05).At day 7 and 14 post-treatment,plasma C-reactive protein and D-dimer concentrations in combined treatment group were obviously lower than those in other three groups(all P<0.05).At 3 month post-treatment,NIHSS scores in combined treatment group were obviously lower than those in other three groups(all P<0.05) and BI scores in combined treatment group were obviously higher than those in other three groups(all P<0.05).CONCLUSION: A positive synergistic interaction between puerarin and compound salvia injection was demonstrated and can benefit the improvement of neurological function after acute hypertensive intracerebral hemorrhage.