盐酸羟考酮控释片与硫酸吗啡控释片在癌性内脏痛患者治疗中的止痛作用及不良反应比较

目的：比较癌性内脏痛患者采用盐酸羟考酮控释片与硫酸吗啡控释片治疗的止痛作用及不良反应。方法选取144例癌性内脏痛患者，依据随机数字表法分为研究组（n=72）和对照组（n=72）。给予研究组患者盐酸羟考酮控释片治疗，给予对照组患者硫酸吗啡控释片治疗。比较两组止痛效果及不良反应。结果研究组患者的解救药物用量显著少于对照组（P﹤0.01）；研究组患者便秘、恶心呕吐发生率分别为22.2%（16/72）、31.9%（23/72），均显著低于对照组的50.0%（36/72）、59.7%（43/72），差异有统计学意义（P﹤0.01）；两组患者疼痛缓解效果比较差异无统计学意义（Z=0.419，P﹥0.05）。结论癌性内脏痛患者采用盐酸羟考酮控释片与硫酸吗啡控释片治疗的止痛作用均较显著，但前者比后者不良反应少。

Analgesic effects and adverse reactions of oxycodone hydrochloride controlled-release tablets and morphine sulfate controlled-release tablets in the treatment of patients with cancer visceral pain

Objective To compare the analgesic effects and adverse reactions of oxycodone hydrochloride controlled-release tablets and morphine sulfate controlled-release tablets in the treatment of patients with cancer visceral pain. Meth-od 144 cases of cancer patients with visceral pain were included in the study, and were randomized as study group (n=72) and control group (n=72) according to a random number table. The study group was given oxycodone hydrochloride controlled-release tablets, while the control group was given morphine sulfate controlled-release tablets, and the analgesic effects and adverse reactions in the two groups were compared. Result The rescue medication use in study group was significantly less than that in control group (P<0.01); The incidences of constipation, nausea and vomiting were 22.2%(16/72) and 31.9%(23/72) in study group, significantly lower than those of control group at 50.0%(36/72) and 59.7%(43/72) (P<0.01), respectively; There were no significant differences observed regarding the analgesic effects between the two groups (Z=0.419, P>0.05). Conclusion The analgesic effects of oxycodone hydrochloride controlled-release tablets and morphine sulfate controlled-release tablets were both obvious in the treatment of patients with cancer visceral pain, while less adverse reactions were observed in the former.