晚期肺癌化疗患者伴静脉血栓栓塞症的相关因素分析

目的：分析晚期肺癌化疗患者伴静脉血栓栓塞症的相关因素。方法回顾性分析晚期肺癌化疗伴静脉血栓栓塞症的53例患者（栓塞组）和晚期肺癌化疗未伴有静脉血栓栓塞症的60例患者（对照组）的临床资料，并对晚期肺癌化疗患者伴静脉血栓栓塞症发生的影响因素进行Logistic回归分析。结果单因素分析表明两组患者的性别、病理分型、高脂血症、高血压、肥胖、糖尿病及血小板计数上升比较，差异均无统计学意义（P﹥0.05）；两组患者的年龄、临床分期、吸烟史、D-二聚体上升及血黏稠度升高比较，差异均有统计学意义（P﹤0.05）。通过对筛选出的影响因素予以多因素Logistic回归分析发现，年龄≥60岁、吸烟史、临床分期为Ⅳ期、D-二聚体上升及血黏稠度升高属于晚期肺癌化疗患者伴有静脉血栓栓塞症的危险因素。结论年龄≥60岁、吸烟史、临床分期为Ⅳ期、D-二聚体上升及血黏稠度升高作为晚期肺癌化疗患者伴有静脉血栓栓塞症的危险因素，在临床中，应加以重视。

Factors related with venous thromboembolism in advanced lung cancer patients with chemotherapy

Objective To analyze the factors influencing the venous thromboembolism in patients with advanced lung cancer treated with chemotherapy. Method Retrospective analyze was performed in 53 patients with advanced lung cancer and venous thromboembolism that were treated with chemotherapy (study group), and 60 cases of advanced lung cancer without venous thromboembolism (control group). Logistic regression analysis was used to analyze the related fac-tors of advanced lung cancer chemotherapy and venous thromboembolism. Result Univariate analysis showed that the gender, pathological classification, hyperlipidemia, hypertension, obesity, diabetes, and platelet counts rise of the two groups were of no significant difference (P>0.05), while the age, clinical stage, smoking history, D-dimer rise and elevat-ed blood viscosity of these patients were significantly different (P<0.05). Multivariate Logistic regression analysis showed that, age≥60 years, positive smoking history, clinical stage IV, D-dimer rise and elevated blood viscosity were the risk factors of venous thromboembolism in advanced lung cancer patients with chemotherapy. Conclusion Age≥60 years, positive smoking history, clinical stage IV, D-dimer rise and elevated blood viscosity were associated with the de-velopment of venous thromboembolism in advanced lung cancer patients receiving chemotherapy, which should be ad-dressed in clinical practice.