Maternal smoking during pregnancy, polymorphic CYP1A1 and GSTM1, and lung-function measures in urban family children |
| |
Authors: | Chen Xinguang Abdulhamid Ibrahim Woodcroft Kimberley |
| |
Affiliation: | aThe Adams Ann Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, USA;bHenry Ford Health System, Detroit, MI, USA |
| |
Abstract: | PurposeUnderstanding the interplay between genes and in-utero tobacco exposure in affecting child lung development is of great significance. In this study, we tested the hypothesis that tobacco-related lung-function reduction in children differs by maternal polymorphic genes Cytochrome P450 1A1 (CYP1A1) and Glutathione S-transferase Mu 1 (GSTM1).Materials and methodsData were collected among 370 children (6–10 years old, 81.6% African-Americans) and their biological mothers visiting a large children’s hospital. Study hypotheses were tested using multiple regression method.ResultsAmong the study sample, 143 mothers smoked throughout pregnancy and 72 smoked on a daily basis. Spirometric measures (mean±SD) included were: forced vital capacity (FVC)=1635±431 mL, forced expiratory volume in the first 1 s (FEV1)=1440 ±360 mL, percent FEV1/FVC ratio=89±12, and forced expiratory flow between the 25% and 75% of FVC (FEF25–75)=1745±603 mL. In addition to a tobacco effect on FVC (−131 mL, 95% CI: −245, −17) and FEV1/FVC ratio (42, 95% CI: 1, 83), regression analysis controlling for covariates indicated that for the subsample of children whose mothers were CYP1A1?2A homozygous, maternal daily smoking was associated with −734 mL (95% CI: −1206, −262) reductions in FEV1 and −825 mL (95% CI: −909, −795) reductions in FVC; reduced smoking was still associated with −590 mL (95% CI: −629, −551) reductions in FVC. For children of mothers with GSTM1 deletion, persistent daily smoking was associated with −176 mL (95% CI: −305, −47) reductions in FVC.Discussion and conclusionsMaternal smoking during pregnancy was significantly associated with lung-function reduction in children, particularly for those whose mothers possessed the polymorphic CYP1A1*2A and GSTM1 deletion. |
| |
Keywords: | Abbreviations: FVC, forced vital capacity FEV1, forced expiratory volume FEF25&ndash 75, forced expiratory flow between the 25% and 75% of FVC SD, standard deviation PCR&ndash RFLP, polymerase chain reaction&ndash restriction fragment length polymorphism CYP1A1, Cytochrome P450 1A1 GSTM1, Glutathione S-transferase Mu 1 |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|