Differential cyclophosphamide sensitivity of suppressor function in Xenopus, the clawed toad |
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| Authors: | R H Clothier Z Last J D Somauroo L N Ruben M Balls |
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| Affiliation: | Department of Human Morphology, University of Nottingham, Queen's Medical Centre, UK. |
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| Abstract: | Thymocyte and Splenocyte cultures from in vivo immunised Xenopus were assayed to test their suppressive capacity. Immunisation with TNP-Polyvinylpyrrolidone induced suppression. Suppression induced by the haptenated antigens, TNP-Red blood cells, TNP-Lipopolysaccharide, and TNP-Ficoll affected the anti-TNP antibody response of splenocytes from TNP-PVP immunised animals. Pretreatment with cyclophosphamide revealed both a sensitive and insensitive suppression capacity in Xenopus laevis. |
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