米非司酮联合地佐辛复合异丙酚在人工流产术中的应用

目的:观察米非司酮联合地佐辛复合异丙酚在人工流产术中的应用效果。方法:360例自愿终止妊娠的初孕妇女随机分为4组,观察各组镇静镇痛效果,宫颈软化效果,扩张宫颈的时间,子宫收缩情况,术中出血量,人工流产综合征发生情况,人工流产术近期并发症。结果:A组、C组(地佐辛镇痛组)镇痛效果满意;B组、D组(芬太尼镇痛组)镇痛效果欠佳,总不良反应发生率地佐辛组明显低于芬太尼组(P<0.05)。A组、B组(米非司酮软化宫颈组)总有效率达100%,充分软化率与C组、D组(空白组)相比有明显统计学差异(P<0.01),但人工流产近期并发症的观察未见统计学差异。结论:镇痛效果优良,宫颈软化率高,扩张宫颈快捷安全,未见人工流产综合征的发生。

The application of mifepristone and dezocine composited with propofol in the induced abortion

OBJECTIVE To observe the effect of application of mifepristone and dezocine composited with propofol in the induced abortion.METHODS 360 cases of the earlier pregnant women were divided into four groups randomly,observed the following indexes : the effects of sedation and analgesia,and the softening of cervix,the time of cervical dilatation,the condition of uterine contractions and artificial abortion syndrome,the blood loss during operation,the short term complication of the induced abortion.RESULTS There were both satisfaction of the effect of sedation and analgesia in group A and C(dezocine analgesia groups);there were satisfaction of the effect of sedation and unsatisfaction of the effect of analgesia in group B and group D(fentanyl analgesia groups).Total adverse reaction incidence rate in dezocine groups was obviously lower than that in fentanyl groups(P < 0.05).In group A and group B(mifepristone groups) the total effective rate of mifepristone in softening of the cervix reached 100%,and the adequate softening rate of cervix was statistically significant higher than group C and group D(P < 0.01).There was no statistically significant difference in the short term complication of the induced abortion.CONCLUSION When mifepristone and dezocine composited with propofol applied in the induced abortion,the effect of analgesia is satisfactory,and with adequate softening rate of cervix,safe and fast of cervical dilatation,with no occurrence of artificial abortion syndrome.