复方白及乳膏中尿素的体外释放度考察

目的：考察复方白及乳膏中尿素的体外释放度,为合理用药提供依据。方法：采用透析袋法研究复方白及乳膏中尿素的体外释药特性,以生理盐水为释放介质,对二甲基苯甲醛试液为染色剂,分光光度法测定含量。结果：2 h内尿素累积释放度为86.0%,为速释期;48 h内累积释放度为99.0%。结论：复方白及乳膏中的尿素具有速释特性,药物释放后易被皮肤迅速吸收,2～3 h可用药一次。透析袋法考察复方白及乳膏中尿素的体外释放度,操作便利、方法稳定、结果重复性好。

Determination of Carbamide Release from Compound Bletilla Striata Creams in vitro

Objective: To provide the foundation for the rational use of compound bletilla striata creams by studying the in vitro release rate.Method: Using saline solution as the release medium,dimethylbenzaldehyde as the colorant,the release rate of carbamide was studied with the dialysis method.The content of carbamide was determined by spectrophotometry.Result: The release rate of carbamide was 86.0% in 2 h and 99.0% in 48 h.Conclusion: The in vitro release of carbamide from compound bletilla striata creams is rapid,suggesting the quick absorption through skin.The creams can be used once every 2-3 h.The determination method is convenient and stable.